Drug information of Gonadorelin

Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.

Absorption:

Rapidly absorbed when injected

Metabolism:

Rapidly hydrolyzed to inactive peptide components

Route of Half life:

Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes

Toxicity:

LD50>3000 mg/kg (rat, oral)

Amenorrhea

Gonadotropin Deficiency

It is used to help women get pregnant.

Usual Adult Dose for Gonadotropin Deficiency:

0.1 mg injected once subcutaneously or intravenously as a single dose.

Usual Adult Dose for Amenorrhea:

5 mcg every 90 minutes (range of 1 to 20 mcg) delivered intravenously by a pump over 1 minute, every ninety minutes for 21 days.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Irritation where the shot is given.

Feeling agitated.

Low mood (depression).

Headache.

Upset stomach.

Very heavy periods (menstrual bleeding).

Belly pain.

Swelling.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

Ovarian hyperstimulation syndrome (OHSS) is a severe side effect that may happen in some women who use gonadorelin. Call your doctor right away if you have severe stomach pain or bloating; very upset stomach, throwing up, or diarrhea; a big weight gain; shortness of breath; or change in how much urine is passed.

Ovarian cancer has rarely happened in women who have been treated to help get pregnant. It is not known if the treatments led to these cases of ovarian cancer. Talk with your doctor.

 tell your doctor BEFORE  take Gonadorelin :

- If you have an allergy to gonadorelin or any other part of gonadorelin.

- If you are allergic to gonadorelin; any part of gonadorelin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

- If you have any of these health problems: Cancer where hormones make it grow, ovarian cysts, a health problem that can get worse from hormones like some types of tumors, or a health problem that can get worse from pregnancy like a pituitary tumor.

- If your ovaries no longer make eggs (primary ovarian failure).

- If you are not able to get pregnant because of problems with your sex organs.If you are breast-feeding or plan to breast-feed.

 
Limit working out while undergoing ovarian stimulation. Talk with your doctor.

This medicine may raise the chance of getting pregnant with more than one baby.

 You will need to have ultrasounds done while using gonadorelin. Talk with your doctor.

 It is given as an infusion into a vein over a period of time.

 It is given as an infusion into the fatty part of the skin over a period of time.

 If you are using gonadorelin in a pump, be sure you know how to use it

Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

If your symptoms or health problems do not get better or if they become worse, call your doctor.