Drug information of Sucralfate

Sucralfate

Drug group:

Sucralfate is an anti-ulcer medication. Sucralfate is not greatly absorbed into the body through the digestive tract. It works mainly in the lining of the stomach by adhering to ulcer sites and protecting them from acids, enzymes, and bile salts. Sucralfate is used to treat an active duodenal ulcer. Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring.

Mechanism of effect

Although the mechanism of Sucralfate’s ability to accelerate healing of duodenal ulcers remains to be fully defined, it is known that it exerts its effect through a local, rather than systemic, action. suggest that Sucralfate’s antiulcer activity is the result of formation of an ulcer-adherent complex that covers the ulcer site and protects it against further attack by acid, pepsin, and bile salts.

Pharmacodynamic

Sucralfate is a prescription medication used to treat peptic ulcers

Pharmacokinetics

Sucralfate is only minimally absorbed from the gastrointestinal tract. The small amounts of the sulfated disaccharide that are absorbed are excreted primarily in the urine.

Dosage

Usual Adult Dose for Duodenal Ulcer
Recommended dose: 1 g orally 4 times a day
Duration of therapy: 4 to 8 weeks
Usual Adult Dose for Duodenal Ulcer Prophylaxis
Oral Tablets:
Recommended dose: 1 g orally 2 times a day
Duration of therapy: Up to 1 year

Alerts

-Controlled studies did not extend beyond 12 months. -Elderly patients: Patients should be started on the low end of the dosing range, and renal function monitoring should be considered. -Renal Dose Adjustments:Use with caution.

Points of recommendation

1-Each dose should be taken on an empty stomach 2-Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Pregnancy level

B


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