Drug information of Cisapride


Drug group:

Cisapride increases the rate at which your esophagus, stomach, and intestines move during digestion. It also increases the rate at which your stomach empties into your intestines and increases the strength of your lower esophageal sphincter (the muscle between your stomach and your esophagus).

Mechanism of effect

Promotes gastric emptying, increases lower esophageal sphincter tone and esophageal peristalsis Increases gastric motility and cardiac rate possibly by releasing acethylcholine at the myenteric plexus; may act at the serotonin-4 receptor


Onset of action : 0.5-1 hr
Bioavailability : 35-40%
Half-life : 6-12 hr
Protein binding : 97.5-98%
Metabolism : Liver(hepatic P450 enzyme CYP3A4)
Excretion : Urine and feces


Gastrointestinal Dysmotility : 5-10 mg PO q6hr at least 15 minutes PC and HS, May need to increase to 20 mg in some patients


Cisapride may cause serious irregular heart beats, which can lead to death. Tell your doctor if you have a family history of heart problems and if you have or have ever had irregular heart beats, heart disease, severe dehydration, vomiting, eating disorders, or kidney or lung failure

Points of recommendation

Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals and at bedtime.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not drink grapefruit juice while taking cisapride.

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