Drug information of Cisapride

Mechanism of effect

Promotes gastric emptying, increases lower esophageal sphincter tone and esophageal peristalsis Increases gastric motility and cardiac rate possibly by releasing acethylcholine at the myenteric plexus; may act at the serotonin-4 receptor

Pharmacokinetics

Onset of action : 0.5-1 hr
Bioavailability : 35-40%
Half-life : 6-12 hr
Protein binding : 97.5-98%
Metabolism : Liver(hepatic P450 enzyme CYP3A4)
Excretion : Urine and feces

Dosage

Gastrointestinal Dysmotility : 5-10 mg PO q6hr at least 15 minutes PC and HS, May need to increase to 20 mg in some patients

Drug contraindications

severe bradycardia , impairment of renal function , hypersensitivity to this drug

Side effects

nausea , Headache , Diarrhea , asthenia , Urinary frequency , stomach pain , Fast or irregular heartbeat

Interactions

Amitriptyline , Erythromycin , Itraconazole , Tetrabenazine , Danazol , Doxepin , Zafirlukast , Sotalol , Sevoflurane , Amiodarone , Imipramine , Trimipramine , Desipramine , Fluphenazine , Fluconazole , protriptyline , Nefazodone , taro clindamycin , sparfloxacin , Sertindole , Procainamide , Nortriptyline , Clarithromycin , Clomipramine , Prochlorperazine , Quinidine , Amoxapine , Ketoconazole , Ranolazine , Pentamidine , Methazolamide , Toremifene , Ziprasidone , Histrelin , ISOPROTERENOL , saquinavir , nelfinavir , Amprenavir , Prednisolone , Dolasetron , Palonosetron , vandetanib , boceprevir , Droperidol , Indinavir , Indapamide , Dofetilide , Inotuzumab‎ , Goserelin , Anagrelide , Promazine , Idelalisib , Torsemide , Vasopressin , Chlorthalidone , Arsenic trioxide , Efavirenz , Tipranavir , Telaprevir , Simeprevir , Etravirine , Halofantrine , Grepafloxacin , Darifenacin , Mibefradil , cobicistat , Delavirdine , Oxiconazole , Terfenadine , Asenapine , Alfuzosin , Amisulpride , Paliperidone , Butabarbital , Perflutren , Pimavanserin , Crizotinib , Lopinavir and Ritonavir , Lorlatinib , Rucaparib , Troleandomycin , gilteritinib , Gadofosveset , glasdegib , Romidepsin , Roxithromycin , oleandomycin , Bepridil , bedaquiline , Dasatinib , Vernakalant , voxelotor , Remoxipride , Ombitasvir, Paritaprevir, and Ritonavir

Alerts

Cisapride may cause serious irregular heart beats, which can lead to death. Tell your doctor if you have a family history of heart problems and if you have or have ever had irregular heart beats, heart disease, severe dehydration, vomiting, eating disorders, or kidney or lung failure

Points of recommendation

Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals and at bedtime.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not drink grapefruit juice while taking cisapride.

Pregnancy level

C

Related drugs

Metoclopramide