Drug information of Silver sulfadiazine
Silver sulfadiazine is an antibiotic. It fights bacteria and yeast on the skin. Silver sulfadiazine topical (for the skin) is used to treat or prevent serious infection on areas of skin with second- or third-degree burns.
Mechanism of effect
the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast.
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Drug indicationsan adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns
Usual Adult Dose for Burns - External Apply to affected areas once or twice a day to a thickness of approximately 1/16 inch.
Drug contraindicationshypersensitivity to drug or its components. , premature infants , newborn infants during the first 2 months of life , pregnant women approaching or at term
Side effectsErythema , burning, stinging, or irritation of the skin , skin discoloration , skin necrosis
1-Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage.it is possible that any adverse reaction associated with sulfonamides may occur. Some of the reactions which have been associated with sulfonamides are as follows:blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia; dermatologic and allergic reactions, including life-threatening cutaneous reactions [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and exfoliative dermatitis]; gastrointestinal reactions, hepatitis and hepatocellular necrosis; CNS reactions; and toxic nephrosis.. 2- If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction. 3- The use of Silver Sulfadiazine Cream, USP 1% in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur.
Points of recommendation
1-Treatment should be continued until satisfactory healing has occurred or until the burn site is ready for grafting. 2- Silver sulfadiazine topical should be applied under sterile conditions.