Drug information of Cyclopentolate

Mechanism of effect

By blocking muscarinic receptors, cyclopentolate produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).

Pharmacodynamic

Cyclopentolate is an anti-muscarinic in the same class as atropine and scopolamine. Cyclopentolate blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. Cyclopentolate thus induces relaxation of the sphincter of the iris and the ciliary muscles.
When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 to 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration in patients who have dark pigmented irises.

Pharmacokinetics

Onset of action : 25-75 min (cycloplegia); 30-60 min (mydriasis)
Duration : < 24hr
Absorption : Minimal systemic
Excretion : urine

Drug indications

Pupillary Dilation

Dosage

Mydriasis/Cycloplegia Diaganosis
1-2 gtt of 1% solution in eye; may repeat in 5 minutes PRN; cycloplegia & mydriasis may last for 24 hours
Use 2% in heavily pigmented iris

Drug contraindications

hypersensitivity to drug or its components.

Side effects

Blurred vision , increased ocular tension , difficulty urinating

Interactions

Acetylcholine , Alprazolam , Esomeprazole , Acetaminophen , Sodium chloride , Sucralfate , Furosemide , Insulin glargine , Combivent (Ipratropium bromide/ Salbutamol) , Prednisolone , spiriva | tiotropium , hypotonic , Lorazepam , Methylprednisolone , Nitrofurantoin , Vitamin C , Vitamin D3 , insulin regular

Alerts

• Transient elevatin in intraocular pressure may occur
• Use caution in patients with Down syndrome (predisposed to angle-closure glaucoma )
• Use with care in children. Talk with the doctor.
• The eldrely may be predisposed to increased intraocular pressure
• The 2% solution may result in psychotic reactions and behavioral disturbances in children 30-45 min following instillation

Points of recommendation

• Wait 5 min between drops
• Minimize absorption by using 1 drop of solution per eye and applying presure over the nasolacrimal sac for 2-3 min
• Avoid driving and doing other tasks or actions that call for clear eyesight while your pupils are dilated.
• Bright lights may bother you. Wear sunglasses.
• This medicine may cause harm if swallowed. If this medicine is swallowed, call a doctor or poison control center right away.
• If the patient is an infant, do not feed your child for 4 hours after your child uses this medicine.

Pregnancy level

C

Related drugs

Tropicamide , Homathropine , Atropine