Drug information of Flurazepam


Drug group:

Flurazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) similar to Valium. Flurazepam affects chemicals in the brain that may become unbalanced and cause sleep problems (insomnia). Flurazepam is used to treat insomnia symptoms, such as trouble falling or staying asleep.

Mechanism of effect

Flurazepam, like other central nervous system agents of the 1,4-benzodiazepine class, presumably exerts its effects by binding to stereo-specific receptors at several sites within the central nervous system (CNS). The exact mechanism of action is unknown.


Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Furthermore, it decreases sleep latency and number of awakenings for a consequent increase in total sleep time


Flurazepam hydrochloride is rapidly absorbed from the gastro-intestinal tract. Flurazepam is rapidly metabolized and is excreted primarily in the urine. Protein binding: 83%.The mean apparent half-life of flurazepam is 2.3 hours.

Drug indications



Usual Adult Dose for Insomnia 30 mg orally before retiring. In some patients, 15 mg may suffice.


1-Withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines. 2-Severe Anaphylactic or Anaphylactoid Reactions, Abnormal Thinking and Behavior Changes,، Daytime Impairment, Worsening of Depression may occure. 3-Use with caution in patients with hepatic dysfunction.

Points of recommendation

1-Ask patients about alcohol consumption, medicines they are taking now, and drugs they may be taking without a prescription. 2-Advise patients that alcohol generally should not be used during treatment with Flurazepam. 3-Tell patients not to increase the dose of Flurazepam on their own, and to inform you if they believe the drug “does not work”.

Pregnancy level


Related drugs

Alprazolam , Midazolam , Triazolam

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