Drug information of Fibrinolysin


Drug group:

Fibrinolysin (also known as bovine plasmin) is a bovine enzyme derived from bovine plasma or extracted from bacterial cultures. Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain  contains the active center of Fibrinolysin . Fibrinolysin is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Fibrinolysin and deoxyribonuclease both act as lytic enzymes.

The combination is available as ointment containing 1 BU (Biological Unit) Fibrinolysin and 666 BUs desoxyribonuclease per gram.

Mechanism of effect

Fibrinolysin attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue.


This medication is for topical or vaginal use only. To apply to the skin, first clean the wound as directed and gently dry the area. Apply a thin layer of ointment and cover the area with gauze or a bandage as recommended. Change the bandage 1 to 3 times a day as directed.

For maximal effects, the wound must be cleaned before applying new ointment. For vaginal use, insert the prescribed amount of ointment deep into the vagina once a night as directed. Do not apply this in large amounts or use this more often than directed. Wash hands well after applying the ointment.


 Tell your doctor if you have: other illnesses, allergies (especially drug allergies). This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor

Points of recommendation

 If the condition for which this was prescribed does not improve or becomes worse after a few days, consult your doctor.

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