Drug information of Griseofulvin

Griseofulvin

Drug group:

This medication is used to treat fungal infections of the skin, hair, and nails that do not respond to creams/lotions.

Mechanism of effect

The mechanism of Griseofulvin consists of binding microtubular proteins, which are
required for mitosis Following oral administration, Griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.

Pharmacodynamic

Griseofulvin is a penicilium antibiotic which inhibit the mitosis of the fungi and don’t have any bacteriocidal or bacteriostatic activity.

Pharmacokinetics

Griseofulvin has a variable elimination half-life in plasma (9 to 24 hours). Approximately 30% of a single oral dose of Griseofulvin is excreted in the urine within 24 hours and about 50% of the dose is excreted in the urine within 5 days, mostly in the form of metabolites. Unchanged Griseofulvin in the urine accounts for less than 1% of the administered dose. In addition, approximately one-third of a single dose of Griseofulvin is excreted in feces within 5 days. Griseofulvin is also excreted in perspiration.

Dosage

Usual adult doses for Oncomycosis-fingernail
Microsize formulation:1000 mg/day orally in 2 to 4 divided doses
Ultramicrosize formulation: 660 to 750 mg/day orally in 2 to 4 divided doses
Usual Adult Dose for Tinea Barbae
Microsize formulation: 500 mg/day orally in single or 2 divided doses
Ultramicrosize formulation: 330 to 375 mg/day orally in single or divided doses
orally in single or divided doses
Usual Adult Dose for Tinea Capitis
Microsize formulation: 500 mg/day orally in single or 2 divided doses
Ultramicrosize formulation: 330 to 375 mg/day orally in single or divided doses
Usual Adult Dose for Tinea Corporis
Microsize formulation: 500 mg/day orally in single or 2 divided doses
Ultramicrosize formulation: 330 to 375 mg/day orally in single or divided doses
Usual Adult Dose for Tinea Cruris
Microsize formulation: 500 mg/day orally in single or 2 divided doses
Ultramicrosize formulation: 330 to 375 mg/day orally in single or divided doses
Usual Pediatric Dose for Dermatophytosis
Microsize formulation:
1 year or older: 10 to 20 mg/kg/day orally in single or divided doses, not to exceed 1000 mg/day
Ultramicrosize formulation:
2 years or younger: Dosage has not been established.
Greater than 2 years: 5 to 15 mg/kg/day in single or divided doses, not to exceed 750 mg/day

Alerts

Before using this medicine, consult your doctor or pharmacist if you have: a certain blood disorder (porphyria), severe liver disease (liver failure).
lupus.
This drug may make you dizzy or less alert. Do not engage in activities requiring alertness such as driving or usin g
Avoid alcoholic beverages while you are taking this drug unless your doctor gives permission. Drinking alcohol during treatment with this drug could result in a fast heartbeat and flushing of the skin.
This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors machinery

Points of recommendation

tell your doctor and pharmacist if you are allergic to griseofulvin, or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thinners') such as warfarin (Coumadin), oral contraceptives, cyclosporine (Neoral, Sandimmune), phenobarbital (Luminal), and vitamins.
tell your doctor if you have or have ever had liver disease, porphyria, lupus, or a history of alcohol abuse.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking griseofulvin, call your doctor.
tell your doctor if you drink alcohol.
you should plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Griseofulvin may make your skin sensitive to sunlight.

Pregnancy level

C

Related drugs

Flucytosine


Ask a Pharmacist


User's questions
    No comments yet.