Drug information of Lansoprazole
Lansoprazole belongs to a group of drugs called proton pump inhibitors. It decreases the amount of acid produced in the stomach. Lansoprazole is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Over-the-counter lansoprazole (Prevacid OTC) is used to treat frequent heartburn that happens 2 or more days per week. Lansoprazole is not for immediate relief of heartburn symptoms.
Mechanism of effect
suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell.
Lansoprazole, an acid proton-pump inhibitor similar to omeprazole
The absorption of lansoprazole is rapid, with mean Cmax occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%. Protein binding: 97%. Metabolism: Hepatic. Following single-dose oral administration of PREVACID, virtually no unchanged lansoprazole was excreted in the urine. In one study, after a single oral dose of 14C-lansoprazole, approximately one-third of the administered radiation was excreted in the urine and two-thirds was recovered in the feces. This implies a significant biliary excretion of the lansoprazole metabolites. Half life: 1.5 (± 1.0) hours.
Drug indicationsHelicobacter pylori Infection , peptic ulcer , Duodenal Ulcer , Erosive Esophagitis , Zollinger-Ellison Syndrome , Gastroesophageal Reflux Disease
Usual Adult Dose for Erosive Esophagitis
Initial dose: 30 mg orally once a day for up to 8 weeks. Alternatively, if the patient is unable to use oral route the dose may be given as an IV infusion of 30 mg per day administered over 30 minutes for up to 7 days.
Maintenance dose: 15 mg orally once a day.
Usual Adult Dose for Duodenal Ulcer
15 mg orally once a day 30 minutes before eating. Therapy should be continued for up to 4 weeks.
Usual Adult Dose for Gastroesophageal Reflux Disease
15 mg orally once a day. Therapy should be continued for up to 8 weeks.
Usual Adult Dose for Gastric Ulcer
30 mg orally once a day 30 minutes before eating. Therapy should be continued for 4 to 8 weeks.
Usual Adult Dose for Zollinger-Ellison Syndrome
60 mg orally once a day. Doses up to 90 mg orally 2 times a day have been used. The manufacturer reports that some patients have been treated continuously for as long as four years.
Usual Pediatric Dose for Gastroesophageal Reflux Disease
Short term treatment of GERD (up to 12 weeks):
1 to 11 years:
Less than or equal to 30 kg = 15 mg once daily
Greater than 30 kg = 30 mg once daily
12 to 17 years: 15 mg once daily for up to 8 weeks
Drug contraindicationshypersensitivity to drug or its components. , in combination with antibacterial agents
Side effectsvomiting , Diarrhea , leukopenia , Hypomagnesemia , Stevens-Johnson syndrome , urinary retention , Anaphylactic reaction , pancreatitis , aplastic anemia,
InteractionsDactinomycin , Cetuximab , Mycophenolate mofetil , Clopidogrel , nelfinavir , Iron , Secretin , Acalabrutinib , Nisoldipine , Sofosbuvir and velpatasvir , Pazopanib , Warfarin , Clarithromycin
1-Symptomatic response to therapy with Lansoprazole does not preclude the presence of gastric malignancy.
2-Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Lansoprazole.
3-Acute interstitial nephritis has been observed in patients taking PPIs including Lansoprazole.
4-Daily treatment with any acid-suppressing medications over a long period of time (e.g., longer than 3 years) may lead to malabsorption of cyanocobalamin (vitamin B-12) caused by hypo-or achlorhydria.
Points of recommendation
• Food reduces bioavailabilty, but this has very little clinical impact. Take 30-60 minutes before meals.