Drug information of Opium

Opium

Drug group:

Opium preparation is an opioid, sometimes called a narcotic.

Opium is derived from the seed pod of a poppy plant. It works by increasing smooth muscle tone and decreasing fluid secretions in the intestines. This slows the movement of bowel matter through the intestines.

Opium preparation (sometimes called "opium tincture") is used to treat diarrhea.

Opium preparation may also be used for purposes not listed in this medication guide

Mechanism of effect

Contains many opioid alkaloids including morphine; its mechanism for gastric motility inhibition is primarily due to this morphine content; it results in a decrease in digestive secretions, an increase in GI muscle tone, and therefore a reduction in GI propulsion

Pharmacodynamic

Storage
Store at 68°F to 77°F (20°C to 25°C). Protect from light.
Absorption
Variable
Metabolism
Hepatic
Excretion
Urine

Drug indications

Diarrhea: Treatment of diarrhea in adults

Dosage

Diarrhea: Oral: 6 mg (0.6 mL) of undiluted opium tincture (10 mg/mL) 4 times daily
Cancer treatment-induced diarrhea (off-label dosing): Based on limited data: Oral: 10 to 15 drops (opium tincture [10 mg/mL]) in water every 3 to 4 hours

Drug contraindications

Use in children; diarrhea caused by poisoning until the toxic material is eliminated from the GI tract

Side effects

Frequency not defined.
Cardiovascular: Bradycardia, hypotension, palpitations, peripheral vasodilation
Central nervous system: Central nervous system depression, depression, dizziness, drowsiness, drug dependence, headache, increased intracranial pressure, insomnia, malaise, restlessness
Gastrointestinal: Anorexia, biliary tract spasm, constipation, nausea, stomach cramps, vomiting
Genitourinary: Decreased urine output, genitourinary tract spasm
Hypersensitivity: Histamine release
Neuromuscular & skeletal: Weakness
Ophthalmic: Miosis
Respiratory: Respiratory depression
Postmarketing and/or case reports: Hypogonadism

Alizapride, Alvimopan, Amphetamines, Anticholinergic Agents, Azelastine (Nasal), Blonanserin,
Brimonidine (Topical), Bromopride, Bromperidol, Cannabidiol, Cannabis, Chlormethiazole,
Chlorphenesin Carbamate, CNS Depressants, Desmopressin, Dimethindene (Topical), Diuretics,
Dronabinol, Droperidol, Eluxadoline, Flunitrazepam, Gastrointestinal Agents (Prokinetic),
Kava Kava, Lemborexant, Lisuride, Lofexidine, Magnesium Sulfate, Methotrimeprazine,
Metoclopramide, MetyroSINE, Minocycline (Systemic), Nabilone, Nalmefene, Naltrexone,
Opioid Agonists, Opioids (Mixed Agonist / Antagonist), Orphenadrine, Oxomemazine,
OxyCODONE, Paraldehyde, Pegvisomant, Perampanel, Piribedil, Pramipexole, Ramosetron,
ROPINIRole, Rotigotine, Rufinamide, Selective Serotonin Reuptake Inhibitors, Serotonergic Agents (High Risk), Sincalide, Sodium Oxybate, Succinylcholine, Suvorexant, Thalidomide,
Tetrahydrocannabinol, Tetrahydrocannabinol and Cannabidiol, Zolpidem

Alerts

This medication is usually taken 1 to 4 times daily to treat diarrhea. Follow all directions on your prescription label. Opium preparation can slow or stop your breathing. Never use opium preparation in larger amounts, or for longer than prescribed

Opium preparation may be habit-forming when used over a long period of time. Never share opium preparation with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away opium preparation is against the law

Each opium preparation contains a different amount of opium. If you switch from using one opium preparation to using another, your dose will not be the same. Some opium preparations are much stronger than others, and taking too much opium may cause serious harm

Do not stop using opium preparation suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using opium preparation

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet

An opium preparation overdose can be fatal, especially in a child or other person using the medicine without a prescription.
Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, and fainting

Do not drink alcohol. Dangerous side effects or death could occur

Avoid using any other anti-diarrhea medications that your doctor has not prescribed

Opium preparation may impair your thinking or reactions. Avoid driving or operating machinery until you know how opium preparation will affect you. Dizziness or severe drowsiness can cause falls or other accidents

Opium tincture contains morphine 10 mg/mL. Use caution in ordering, dispensing, and/or administering. Doses may be expressed in mg (milligram) dosing units of morphine or as drops

Points of recommendation

Do not use opium preparation if the safety seal on the cap is broken or missing

Opium preparation should not be given to treat diarrhea that is caused by poisoning (until the toxin is no longer in the digestive tract).

To make sure opium preparation is safe for you, tell your doctor if you have ever had:
asthma, emphysema, or other breathing problem
stomach bleeding
a head injury, brain tumor
a seizure
a stroke
cirrhosis or other liver disease
underactive thyroid
enlarged prostate, urination problems
alcoholism or drug addiction

Pregnancy level

B

 B; D if used for prolonged periods or near term

Breast feeding warning

Long-term effect unknown

Related drugs

fentanyl , Tapentadol , Butorphanol

Drug forms

Opium Deodorized, Paregoric

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