Drug information of Loratadin


Long-acting tricyclic histamine H1 antagonist, Piperidine Derivative
Histamin can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Loratadine is an antihistamine that reduces these nasal and non-nasal symptoms of seasonal allergic rhinitis (eg, sneezing, runny nose, itchy or burning eyes). It is also used to treat skin hives and itchinh.

Mechanism of effect

Antihistamine with selective peripheral histamine H1-receptor antagonist activity and sedative effects are also seen.


Competes with histamine for H1-receptor sites on effector cells.


Time to peak: 8 to12 hours
Metabolism: Hepatic
Half-life elimination: ~12-15 hours
Excretion: Urine; feces
Small amounts of loratadin may be excreted in breast milk

Drug indications

Urticaria , Allergic Rhinitis


• Allergic rhinitis:
Oral: 10 mg qDay or 5 mg twice daily; not to exceed 10 mg/day
Urticaria: Oral: 10 mg qDay; not to exceed 10 mg qDay
• Allergic rhinitis:
<2 years: Oral: Efficacy not established
2 to <6 years: Oral: 5 mg qday
>6 years :10 mg qday; not to exceed 10 mg qDay
• Urticaria:
<6 years: Efficacy not established
>6 years: 10 mg qDay

Drug contraindications

hypersensitivity to this drug


Use with caution in patients with hepatic and renal impairment and also in elderly patients.
Effects of ethanol and other sedative drugs may be potentiated when used concurrently.

Points of recommendation

May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving).
May be administered without regard to meals.

Pregnancy level


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