Drug information of Levofloxacin

Levofloxacin

Drug group:

Levofloxacin is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Levofloxacin fights bacteria in the body. Levofloxacin is used to treat bacterial infections of the skin, sinuses, kidneys, bladder, or prostate. Levofloxacin is also used to treat bacterial infections that cause bronchitis or pneumonia, and to treat people who have been exposed to anthrax or plague.

Mechanism of effect

Levofloxacin is a member of the fluoroquinolone class of antibacterial agents. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase.

Pharmacodynamic

Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.

Pharmacokinetics

Levofloxacin is rapidly and essentially completely absorbed after oral administration. The mean volume of distribution of levofloxacin generally ranges from 74 to 112 L after single and multiple 500 mg or 750 mg doses, indicating widespread distribution into body tissues Levofloxacin undergoes limited metabolism in humans and is primarily excreted as unchanged drug in the urine

Dosage

Usual Adult Dose for Nosocomial Pneumonia 750 mg orally or IV every 24 hours for 7 to 14 days Usual Adult Dose for Bronchitis Acute bacterial exacerbation of chronic bronchitis: 500 mg orally or IV once a day for 7 days.

Alerts

1-Fluoroquinolones, including Levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants 2-Fluoroquinolones, including Levofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid Levofloxacin in patients with a known history of myasthenia gravis

Points of recommendation

1-Antibacterial drugs including Levofloxacin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). 2-Levofloxacin Oral Solution should be taken 1 hour before or 2 hours after eating. The oral solution should be taken at the same time each day 3-Patients should drink fluids liberally while taking Levofloxacin to avoid formation of a highly concentrated urine and crystal formation in the urine 4-Antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc or didanosine should be taken at least two hours before or two hours after oral Levofloxacin administration.

Pregnancy level

C


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