Drug information of Iothalamate Meglumine

Iothalamate Meglumine

Drug group:

It is used before an x-ray or an alike test.
Conray is indicated for use in excretory urography, cerebral angiography, peripheral arteriography, venography, arthrography, direct cholangiography, endoscopic retrograde cholangiopancreatography, contrast enhancement of computed tomographic brain images, cranial computerized angiotomography, intravenous digital subtraction angiography and arterial digital subtraction angiography.

Pharmacokinetics

Absorption:
Renal accumulation is sufficiently rapid that maximum radiographic density in the calyces and pelves occurs, in most instances, about 3 to 8 minutes after injection. In patients with impaired renal function, diagnostic opacification frequently is achieved only after prolonged periods.
Protein binding :
Iothalamate salts are poorly bound to serum albumin.
Route of elimination:
Following intravascular injection, Conray is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine by glomerular filtration. The liver and small intestine provide the major alternate route of excretion. In patients with severe renal impairment, the excretion of this contrast medium through the gallbladder and into the small intestine sharply increases.
Half life :
In patients with normal renal function, the alpha and beta half-lives of Conray were approximately 10 and 90 minutes, respectively.

Drug indications

It is used before an x-ray or an alike test.
Conray is indicated for use in excretory urography, cerebral angiography, peripheral arteriography, venography, arthrography, direct cholangiography, endoscopic retrograde cholangiopancreatography, contrast enhancement of computed tomographic brain images, cranial computerized angiotomography, intravenous digital subtraction angiography and arterial digital subtraction angiography. Conray may also be used for enhancement of computed tomographic scans performed for detection and evaluation of lesions in the liver, pancreas, kidneys, abdominal aorta, mediastinum, abdominal cavity and retroperitoneal space.

Dosage

 

Side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Sneezing.
- Stuffy nose.
- Cough.
- Choking.
- Shortness of breath.
- Blue or gray skin color.
- Chest pain or pressure.
- Fast or abnormal heartbeat.
- Very bad dizziness or passing out.
-Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Seizures.
- Very bad skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen from 1 hour to several weeks after getting this drug. These skin reactions can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Injection (if given in an artery or vein):
This drug may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
For all uses of this drug:
-Flushing.
-Feeling of warmth.
-Sweating a lot.
-Upset stomach or throwing up.
-For use in the bladder:
-Irritation where this drug is used.

amikacin liposome ,amphotericin b cholesteryl sulfate ,amphotericin b lipid complex 

Alerts

- This drug must not be given into the spine.
- Very bad health problems, paralysis, and death have happened when contrast has been given into blood vessels in the spinal cord. Talk with the doctor.

 it is need to tell your doctor BEFORE :

- If you are allergic to iothalamate meglumine; any part of iothalamate meglumine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are dehydrated, have been eating poorly, or have used a laxative or water pill before iothalamate meglumine.
- If you have had a skin reaction to iothalamate meglumine or another drug like it in the past.
-If you are taking metformin.
-If you are breast-feeding. Do not breast-feed after getting iothalamate meglumine for as long as your doctor has told you.

If used before an x-ray of a joint:

- If you have an infection in or near the joint being x-rayed.
- If used before an x-ray of the liver or bile duct:
- If you have a blood clotting problem, talk with your doctor.

If used before an endoscopy:

- If you have pancreatitis, talk with your doctor.
- If you have a certain bile duct problem (cholangitis).

Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your doctor.

Health problems like blood clots have happened with iothalamate meglumine when used with some procedures. Sometimes, blood clots may cause heart attack and stroke, which may be deadly. If you have questions, talk with the doctor.

Seizures and death have happened when contrast has been given to people with bleeding in the brain. Talk with the doctor.

Very bad kidney problems and sometimes death have happened when contrast has been given to people with multiple myeloma. Talk with the doctor.

Thyroid problems have happened after use of iothalamate meglumine. Some people had to be treated for these thyroid problems. Talk with the doctor.

A severe and sometimes deadly reaction has happened. Most of the time, this
reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor.

If you have sickle cell disease, talk with your doctor.

Points of recommendation

- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take iothalamate meglumine.

- If you are 65 or older, use iothalamate meglumine with care. You could have more side effects.

- Use with care in children. Talk with the doctor.

- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using iothalamate meglumine while you are pregnant.

- This medicine is given as a shot into a vein or artery only.

- Some products may be given into the bladder.

-Other drugs may be given before iothalamate meglumine to help avoid side effects.
- You will need to be sure that you are not dehydrated before getting iothalamate meglumine. Check with your doctor to see if you need to drink extra fluids before getting iothalamate meglumine.

- Drink lots of noncaffeine liquids after using iothalamate meglumine unless told to drink less liquid by your doctor.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
storage
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

Pregnancy level

B

Use is not recommended unless clearly needed.
Intravascular contrast agents may cross the placenta and can potentially produce transient fetal hypothyroidism. Reproduction studies in animals have revealed no evidence of impaired fertility or harm to the fetus. There are no adequate and well controlled studies in pregnant women.


Breast feeding warning

Breastfeeding is not recommended during use of this drug.
Excreted into human milk: Yes (unchanged)
Comments:
-The effects in the nursing infant are unknown.
-Use bottle feeding for 24 hours following the administration of this drug.

Drug forms

Conray 30, Conray 43, Conray, Cysto-Conray II

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