Drug information of Minocycline

Minocycline

Drug group:

Minocycline is a tetracycline antibiotic that fights bacteria in the body. Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others.

Mechanism of effect

The mechanism of action of Arestin® as an adjunct to scaling and root planing procedures for reduction of pocket depth in patients with adult periodontitis is unknown.

Pharmacodynamic

Minocycline, a member of the tetracycline class of antibiotics, has a broad spectrum of activity. It is bacteriostatic and exerts its antimicrobial activity by inhibiting protein synthesis

Pharmacokinetics

The mean+/-SD elimination half-life was 7.70+/-1.91 hours. The total body clearance was 0.16+/-0.04 L/h/kg, and the volume of distribution at steady state was 1.53+/-0.09 L/kg. The percentage of plasma protein binding was 68.1+/-2.6%. Plasma concentration of free minocycline was 0.12 microg/mL at 12 hours. Minocycline was not detected in brain tissue, CSF or aqueous humor at 0.5 hours; however, it was found in all tissues, except in the aqueous humor, at 3 hours.

Dosage

Usual Adult Dose for Acne Immediate-release formulations: Initial dose: 50 to 100 mg orally twice a day for 3 to 6 weeks or until improvement occurs Maintenance dose: 50 to 100 mg orally once a day Usual Adult Dose for Bacterial Infection Oral: 200 mg initially followed by 100 mg orally every 12 hours; alternatively, 100 to 200 mg initially followed by 50 mg orally 4 times a day has been used IV: 200 mg initially followed by 100 mg IV every 12 hours (maximum dose: 400 mg/24 hours) Usual Pediatric Dose for Bacterial Infection Above 8 years of age: 4 mg/kg orally or IV initially followed by 2 mg/kg every 12 hours

Alerts

1-THE USE OF DRUGS OF THE TETRACYCLINE CLASS DURING TOOTH DEVELOPMENT (LAST HALF OF PREGNANCY, INFANCY, AND CHILDHOOD TO THE AGE OF 8 YEARS) MAY CAUSE PERMANENT DISCOLORATION OF THE TEETH (YELLOW-GRAY BROWN) 2-Enamel hypoplasia has also been reported. TETRACYCLINE DRUGS, THEREFORE, SHOULD NOT BE USED IN THIS AGE GROUP, OR IN PREGNANT OR NURSING WOMEN, UNLESS THE POTENTIAL BENEFITS ARE CONSIDERED TO OUTWEIGH THE POTENTIAL RISKS. 3-Post-marketing cases of anaphylaxis and serious skin reactions such as Stevens-Johnson syndrome and erythema multiforme have been reported with oral minocycline.

Points of recommendation

1-After treatment, patients should avoid chewing hard, crunchy, or sticky foods (i.e., carrots, taffy, and gum) with the treated teeth for 1 week, as well as avoid touching treated areas 2-Patients should also postpone the use of interproximal cleaning devices around the treated sites for 10 days after administration of Arestin®

Pregnancy level

D


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