Drug information of Troleandomycin

Troleandomycin

Drug group:

A macrolide antibiotic that is similar to erythromycin. For the treatment of bacterial infection

Mechanism of effect

As a macrolide, troleandomycin binds to the 50S subunit of the bacterial ribosome . This binding inhibits translocation of tRNA along the A, P, and E sites of the ribosome. With tRNA unable to move from site to site, amino acids cannot be deposited onto the polypeptide chain leading to failure of protein synthesis. Bacterial cell growth and duplication is inhibited without the ability to generate the necessary proteins

Pharmacodynamic

Troleandomycin, like other macrolide antibiotics, inhibits bacterial protein synthesis to prevent growth

Pharmacokinetics

not available

Drug indications

pneumonia

Dosage

cap 250 mg

Usual Adult Dose for Pneumonia

250 to 500 mg orally 4 times a day.

Usual Adult Dose for Streptococcal Infection

250 to 500 mg orally 4 times a day.

Usual Pediatric Dose for Pneumonia

The safety and efficacy of troleandomycin in children < 1 year have not been established.

>= 1 year: 125 to 250 mg every 6 hours.

When used in streptococcal infections, therapy should be continued for 10 days.

<pstyle="text-align: left;">Usual Pediatric Dose for Streptococcal Infection

The safety and efficacy of troleandomycin in children < 1 year have not been established.

>= 1 year: 125 to 250 mg every 6 hours.

When used in streptococcal infections, therapy should be continued for 10 days.

Drug contraindications

Hypersensitivity to this drug

Side effects

Diarrhea , nausea , vomiting , skin rush

Alerts

Troleandomycin inhibits clearance of theophylline and can increase the likelyhood of toxicity in patients recieving theophylline therapy
Troleandomycin is primarily excreted by the liver and may accumulate in patients with impaired hepatic function. In addition, the use of troleandomycin has been associated with an allergic type of cholestatic hepatitis, particularly in patients receiving the drug for more than 2 weeks or given repeated courses. Therapy with troleandomycin should be administered cautiously in patients with liver and/or biliary disease.

Points of recommendation

 Liver function tests should be monitored during prolonged or repeated courses of therapy, and the drug discontinued if abnormalities develop.

Pregnancy level

HAVE NOT BEEN ESTABLISHED

Drug forms

triocetin-tekmisin-TAO

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