Drug information of Metipranolol


Metipranolol ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma

Mechanism of effect

Metipranolol blocks beta1 and beta2 (non-selective) adrenergic receptors


action of Metipranolol ophthalmic solution, as measured by a reduction in intraocular pressure, occurs within 30 minutes after a single administration. The maximum effect occurs at about 2 hours. A reduction in intraocular pressure can be demonstrated 24 hours after a single dose.

Drug indications



Usual Adult Dose for Glaucoma  and Intraocular Hypertension

One drop in the affected eye(s) twice a day

Side effects

Check with your doctor immediately if any of the following side effects occur while taking metipranolol ophthalmic:

  • Bloody nose
  • blurred vision
  • burning, dry, or itching eyes
  • changes in vision
  • chest pain or discomfort
  • cough producing mucus
  • difficult or labored breathing
  • difficulty in moving
  • difficulty seeing at night
  • difficulty swallowing
  • discharge, excessive tearing
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • headache
  • hives
  • increased sensitivity of eyes to sunlight
  • itching
  • lightheadedness, dizziness, or fainting
  • muscle pain or stiffness
  • nausea
  • nervousness
  • pain in forehead
  • pain or discomfort in arms, jaw, back, or neck
  • pain, swelling, or redness in joints
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness, pain, swelling, or itching of the eye, eyelid, or inner lining of eyelid
  • shortness of breath
  • skin rash
  • sweating
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
  • vomiting

  • Artificial Tears (ocular lubricant ophthalmic)
  • Aspir 81 (aspirin)
  • Coenzyme Q10 (ubiquinone)
  • Dilantin (phenytoin)
  • GlipiZIDE XL (glipizide)
  • Janumet (metformin / sitagliptin)
  • Levaquin (levofloxacin)
  • Lipitor (atorvastatin)
  • Plavix (clopidogrel)
  • Valturna (aliskiren / valsartan)
  • Vitamin B12 (cyanocobalamin)
  • Zetia (ezetimibe)

Points of recommendation

Patients should be instructed to avoid allowing the tip of the dispensing containers to contact the eye or surrounding structures.

 Patients should be advised that Metipranolol contains benzalkonium chloride which may be absorbed by soft contact lenses.

 Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following Metipranolol administration.

 Store at controlled room temperature, 15°-30°C

Replace cap immediately after use.

Pregnancy level


US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans

Breast feeding warning

The effects in the nursing infant are unknown.

Drug forms


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