Drug information of Bendroflumethiazide

Bendroflumethiazide


A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.

Mechanism of effect

As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

Pharmacodynamic

Bendroflumethiazide removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood.

Pharmacokinetics

Absorption: Absorbed relatively rapidly after oral administration

Protein binding: 96%

Half life: 8.5 hours

Drug indications

Hypertension

Dosage

Adults
For fluid retention: Initially 5 mg to 10 mg once a day in the morning or on alternate days. The maintenance dose is 2.5 mg to 5 mg two or three times a week.
For high blood pressure: 2.5 mg once a day in the morning.
Children
The dose will depend on the body weight of the child and the condition being treated, and may be given using a more appropriate formulation (i.e. a liquid).

Alerts

Contains lactose.

diabetes
• porphyria
• gout
• systemic lupus erythematosus (SLE) which is a destructive skin condition
• liver disease (cirrhosis), including that caused by alcohol
• kidney or liver function problems

• inflammation of the pancreas (pancreatitis)
• prostate problems
• high blood lipid levels.

Points of recommendation

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with
the regular dosing schedule. DO NOT DOUBLE THE DOSE.

Alcohol consumption should be kept to a minimum as this medicine increases the likelihood of dehydration after drinking alcohol.
This medicine may cause dizziness. Do not drive or operate machinery if it has this effect on you.


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