Drug information of Efinaconazole


Drug group:

Efinaconazole is a triazole antifungal. This medication is used to treat toenail infection caused by fungus. Infections that may cause nail discoloration, splitting, or pain.


Efinaconazole topical solution is in a class of medications called antifungals. It works by stopping the growth of nail fungus.


mean ± SD plasma Cmax on Day 28 of treatment: 0.67 ± 0.37 ng/mL. mean ± SD AUC was 12.15 ± 6.91 ng*h/mL

Half life: 29.9 hours in healthy patients.

Drug indications

Treatment of fungal infection of the nail, known as onychomycosis.


Before applying this medication, clean and dry the infected toenail(s). Wait at least 10 minutes after showering, bathing, or washing before applying. Use this medication only on the infected toenail(s) as directed by your doctor, usually once daily for 48 weeks. If this medication is used on a child, an adult should apply it for them.

Drug contraindications

Hypersensitivity to this drug or components

Hypersensitivity to efinaconazole or any component of the formulation.


There are no known significant interactions.


  • Local irritation: Persistent local pain, irritation, or dermatitis may develop. If this occurs, contact health care provider.

Points of recommendation

  • Inform patient report immediately to prescriber severe application site irritation or ingrown toenail
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat).

Pregnancy level


Related drugs

Ciclopirox , Butenafine

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