Drug information of Muromonab-CD3

Muromonab-CD3

Drug group:

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a)

Mechanism of effect

Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

Pharmacodynamic

Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients

Pharmacokinetics

Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production

Drug indications

reduce immune system for organ transplant.

Side effects

Less common

  1. Chest pain
  2. rapid or irregular heartbeat
  3. shortness of breath or wheezing
  4. swelling of face or throat

Check with your doctor as soon as possible if any of the following side effects occur:

More common

  1. Diarrhea
  2. dizziness or faintness
  3. fever and chills
  4. general feeling of discomfort or illness
  5. headache
  6. muscle or joint pain
  7. nausea and vomiting

Less common or rare

  1. Confusion
  2. black, tarry stools
  3. blood in urine or stools
  4. convulsions (seizures)
  5. cough or hoarseness
  6. hallucinations (seeing, hearing, or feeling things that are not there)
  7. itching or tingling
  8. loss of hearing or vision
  9. lower back or side pain
  10. painful or difficult urination
  11. pinpoint red spots on skin
  12. skin rash
  13. sores, ulcers, or white spots on the lips or in the mouth
  14. stiff neck
  15. swollen or painful glands
  16. tightness in the chest
  17. trembling and shaking of hands
  18. troubled breathing
  19. unusual sensitivity of eyes to light
  20. unusual bleeding or bruising
  21. unusual tiredness
  22. weakness

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Tofacitinib

Alerts

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pregnancy level

C

Breast feeding warning

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine

Drug forms

Orthoclone OKT 3

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