Drug information of Ioxaglate

Ioxaglate

Drug group:

Ioxaglate is used before an x-ray or an alike test.

Mechanism of effect

 

Drug indications

It is used before an x-ray or an alike test.

Hexabrix is indicated for use in pediatric angiocardiography, selective coronary arteriography with or without left ventriculography, peripheral arteriography, aortography, selective visceral arteriography, cerebral angiography, intra-arterial digital subtraction angiography, intravenous digital subtraction angiography, peripheral venography (phlebography), excretory urography, contrast enhancement of computed tomographic head imaging and body imaging, arthrography and hysterosalpingography.

Dosage

 

Drug contraindications

Hexabrix is contraindicated for use in myelography. Refer to PRECAUTIONS, General, concerning hypersensitivity. Hysterosalpingography should not be performed during the menstrual period; in pregnant patients; in patients with known infection in any portion of the genital tract; or in patients in whom cervical conization or curettage has been performed within 30 days.

Side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up
  •  
  • , or yellow skin or eyes.
  • Sneezing.
  • Stuffy nose.
  • Cough.
  • Choking.
  • Shortness of breath.
  • Blue or gray skin color.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Very bad dizziness or passing out.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Seizures.
  • This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
  • Very bad skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen from 1 hour to several weeks after getting this drug. These skin reactions can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Flushing.
  • Feeling of warmth.
  • Upset stomach or throwing up.

cholesteryl sulfate , amphotericin b lipid complex  ,  lutetium lu 177 dotatate , mesalamine  

Alerts

Before taking this medicine

For all uses of ioxaglate meglumine and ioxaglate sodium:

  • If you have an allergy to ioxaglate meglumine, ioxaglate sodium, or any other part of ioxaglate meglumine and ioxaglate sodium.
  • If you are allergic to ioxaglate meglumine and ioxaglate sodium; any part of ioxaglate meglumine and ioxaglate sodium; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are dehydrated, have been eating poorly, or have used a laxative or water pill before ioxaglate meglumine and ioxaglate sodium.
  • If you have had a skin reaction to ioxaglate meglumine and ioxaglate sodium or another drug like it in the past.
  • If you are taking metformin.
  • If you are breast-feeding. Do not breast-feed for 24 hours after getting ioxaglate meglumine and ioxaglate sodium.

If used before an x-ray of the uterus and fallopian tubes:

  • If you are having your menstrual period or you have a genital infection.
  • If you have had a type of tissue taken out (curettage) or a type of cervix biopsy (conization) within the past 30 days.
  • If you are pregnant or may be pregnant. Do not take ioxaglate meglumine and ioxaglate sodium if you are pregnant.

If used before an x-ray of a joint:

  • If you have an infection in or near the joint being x-rayed.

Tell all of your health care providers that you take ioxaglate meglumine and ioxaglate sodium. This includes your doctors, nurses, pharmacists, and dentists.

Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.

Health problems like blood clots have happened with ioxaglate meglumine and ioxaglate sodium when used with some procedures. Sometimes, blood clots may cause heart attack and stroke, which may be deadly. If you have questions, talk with the doctor.

Seizures and death have happened when contrast has been given to people with bleeding in the brain. Talk with the doctor.

Very bad kidney problems and sometimes death have happened when contrast has been given to people with multiple myeloma. Talk with the doctor.

Thyroid problems have happened after use of ioxaglate meglumine and ioxaglate sodium. Some people had to be treated for these thyroid problems. Talk with the doctor.

A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor.

If you have sickle cell disease, talk with your doctor.

This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take ioxaglate meglumine and ioxaglate sodium.

If you are 65 or older, use ioxaglate meglumine and ioxaglate sodium with care. You could have more side effects.

Use with care in children. Talk with the doctor.

This medicine is given as a shot into a vein or artery only.

Other drugs may be given before ioxaglate meglumine and ioxaglate sodium to help avoid side effects.

You will need to be sure that you are not dehydrated before getting ioxaglate meglumine and ioxaglate sodium. Check with your doctor to see if you need to drink extra fluids before getting ioxaglate meglumine and ioxaglate sodium.

Drink lots of noncaffeine liquids after using ioxaglate meglumine and ioxaglate sodium unless told to drink less liquid by your doctor.

Points of recommendation

Storage:

Store below 30°C (86°F). Do not freeze. If product is frozen or if crystallization of the salt has occurred, examine the container for physical damage. If no damage has occurred, the container should be brought to room temperature. Shake vigorously to assure complete dissolution of any crystals. The speed of dissolution may be increased by heating with circulating warm air. Before use, examine the product to assure that all solids are dissolved and that the container and closure have not been damaged.

Pregnancy level

B

Use is not recommended unless clearly needed.

US FDA pregnancy category: B

Comment: This drug cross the placental barrier.

Reproduction studies have been performed in rats, and rabbits at doses up to two times the maximum adult human dose and have revealed no evidence of impaired fertility or harm to the fetus. There are no adequate and well controlled studies in pregnant women.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Breast feeding warning

Breastfeeding is not recommended during use of this drug.

Excreted into human milk: Yes

Comments:
-The effects in the nursing infant are unknown.
-Use bottle feeding for 24 hours following the administration of this drug.

Drug forms

Hexabrix

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