Drug information of oleandomycin

oleandomycin

Drug group:

Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus.
Oleandomycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces antibioticus. It is weaker than erythromycin.
Oleandomycin can be employed to inhibit the activities of bacteria responsible for causing infections in the upper respiratory tract much like Erythromycin can. Both can affect Staphylococcus and Enterococcus genera
Oleandomycin is approved as a veterinary antibiotic in some countries. It has been approved as a swine and poultry antibiotic in the United States. However, it is currently only approved in the United States for production uses

Mechanism of effect

The drug's mode of action is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis.

Pharmacodynamic

oleandomycin is a CYP3A4 inhibitor that may cause drug interactions

Pharmacokinetics

oleandomycin is principally excreted by the liver.

Dosage

Usual Adult Dose for Pneumonia

250 to 500 mg orally 4 times a day.


Usual Adult Dose for Streptococcal Infection

250 to 500 mg orally 4 times a day.

Usual Pediatric Dose for Pneumonia

The safety and efficacy of troleandomycin in children < 1 year have not been established.

>= 1 year: 125 to 250 mg every 6 hours.

When used in streptococcal infections, therapy should be continued for 10 days.

Usual Pediatric Dose for Streptococcal Infection

The safety and efficacy of troleandomycin in children < 1 year have not been established.

>= 1 year: 125 to 250 mg every 6 hours.

When used in streptococcal infections, therapy should be continued for 10 days.

Drug contraindications

Hypersensitivity to this drug

Interactions

Amiodarone , Ethinyl estradiol+ drospirenone , Ergotamine-C , Erythromycin , Everolimus , Irinotecan , silodosin , Venetoclax , Avapritinib , ubrogepant , Capmatinib , lurasidone , vorapaxar , zanubrutinib , tazemetostat , Macitentan , voxelotor , lefamulin , osilodrostat , selpercatinib , lemborexant , lumateperone , eszopiclone , Brexpiprazole , conivaptan , bosutinib , Dasatinib , levomethadyl acetate , neratinib , gilteritinib , glasdegib , Ceritinib , Eliglustat , Suvorexant , Ruxolitinib , Naloxegol , Cerivastatin , Lorlatinib , Larotrectinib , Anisindione , Siponimod , Istradefylline , Cabozantinib , Cariprazine , Cobimetinib , Levomilnacipran , Temsirolimus , Fedratinib , ivosidenib , Sonidegib , Crizotinib , Avanafil , Entrectinib , trabectedine , Duvelisib , encorafenib , midostaurin , pexidartinib , elagolix , Butorphanol , olaparib , Ibrutinib , Isavuconazonium , Iloperidone , Pimavanserin , Terfenadine , Fesoterodine , Alfuzosin , Erdafitinib , Pazopanib , Palbociclib , Simeprevir , Acalabrutinib , Maraviroc , Halofantrine , Darifenacin , Fostamatinib , Ticagrelor , Guanfacine , DihYDROCODONE , brigatinib , Ponatinib , Copanlisib , Mifepristone , Tofacitinib , Alfentanil , Osimertinib , Panobinostat , Ribociclib , Axitinib , dronedarone , eletriptan , valbenazine , Vilazodone , Ivabradine , Toremifene , Quinidine , Oxycodone , Lomitapide , Mipomersen , teriflunomide , eplerenone , fentanyl , ergonovine , Ranolazine , astemizole , Quetiapine , Vinblastin , Vinorelbine , Cabergoline , Carbamazepine , Colchicine , Daclatasvir , Cisapride , Cilostazol , Cyclosporine , Lapatinib , Nilotinib , Warfarin , Budesonide , Deflazacort , Docetaxel , Dihydroergotamine , Disopyramide , Sirolimus

Alerts

oleandomycin is principally excreted by the liver. Caution should be used when administering the drug to patients with liver dysfunction.
Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic- associated colitis. The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus. The most common culprits are clindamycin, lincomycin, the aminopenicillins (amoxicillin, ampicillin), and the cephalosporins. Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. There is some evidence that pseudomembranous colitis, if it occurs, may run a more severe course in these patients and that it may be associated with flares in their underlying disease activity. The offending antibiotic(s) should be discontinued if significant diarrhea occurs during therapy. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. A large bowel endoscopy may be considered to establish a definitive diagnosis in cases of severe diarrhea.
Prolonged cardiac repolarization and QT interval have been reported in patients receiving treatment with macrolides. Providers should weight risks and benefits of using these drugs in patients with known prolongation of the QT interval, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, or patients receiving other drugs that prolong the QT interval.

Points of recommendation

 Liver function tests should be monitored during prolonged or repeated courses of therapy, and the drug discontinued if abnormalities develop.

Pregnancy level

HAVE NOT BEEN ESTABLISHED

Related drugs

Troleandomycin , Erythromycin , Clarithromycin , Fidaxomicin

fidaxomicin

Drug forms

Sigmamycine. Mastalone . Mastiguard

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