Drug information of Modafinil

Modafinil

Drug group:

Modafinil is a racemic compound . Modafinil and its R-enantiomer armodafinil are central nervous system stimulants used to improve wakefulness in patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea and  shift work sleep disorder.  modafinil  tablets doses contain 100 mg and 200 mg .

Mechanism of effect

Unknown; may increase dopamine level in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake.

Pharmacodynamic

Modafinil has wake-promoting actions like amphetamins contain sympathomimetic effect although the pharmacologic profile is not identical to that of sympathomimetic amines.

It does not change the release of dopamine and norepinephrine in order to stimulate the central nervous system, and it does not make sense of pleasure and Euphoria.

Pharmacokinetics

Absorption: After single or multiple oral doses, modafinil is readily absorbed, reaching maximum plasma concentrations at 2-4 hours after administration.

Distribution: protein bound : 60%

Metabolism:  metabolized in liver and main metabolic of it is acid modafinil, that is in active

Elimination: half life: 15 hr

Excretion: urine (80%)

Dosage

In the treatment of daily sleepiness associated with narcoleptic syndrome and obstructive sleep apnea, administered orally at a dose of 200 to 400 mg per/ day in two divided doses in the morning and midday or as a single dose in the morning.

 To treat shift work sleep disorder , a single dose of 200 mg can be taken one hour before start to work.

 In the elderly, the initial dose is 100 mg / day should be prescribed, adjusted if necessary.

Alerts

Cautions:  use with caution in severehepatic impairment , elderly history of depression, psychosis or mania .risk of skin reactions and discountinue if rash or other hypersensitivity reactions or angioedema or anaphylaxis occur.

Not recommended in patients with angina, cardiac ischemia ,arrhythmia, recent history of myocardial infarction, left ventricular hypertrophy, or mitral valve prolapsed.

Points of recommendation

  • In beginning of use avoid the activity that need attention and consciousness
  • Changes in the amount of drug taken at any time and discontinuation of the drug should be done by the physician.
  • Check your blood pressure regularly and accurately.
  • if you have diabetes, check your blood sugar regularly and periodically attention to your doctor for nutritional recommendations that gives you.
  • Take caution in the elderly.
  • Take the medicine at the recommended dose at any time.
  • Warn the patient about the likelihood of failure of contraceptive methods during treatment with this drug

Pregnancy level

C


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