Drug information of Benorilate
This product is aspirin and acetaminophen ester bond with the neutral compounds. There is antipyretic analgesic effect, adverse reactions than aspirin small, the patient is easy to tolerate, after oral administration in the gastrointestinal tract is not hydrolyzed, absorbed in the intestine and quickly reached an effective concentration in the blood, is characterized by little cause gastrointestinal bleeding.
Mechanism of effect
blocking the synthesis of prostaglandins
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects..
it is rapidly metabolised to salicylate and paracetamol
Drug indicationsPain , Migraine , Headache , fever , myalgia , Arthralgia , toothache , musculoskeletal pain , dysmenorrhea , joint or muscle pain , Dysmenorrhea , Reduces pain and promotes Joint Health
[Specification] 0.5 grams
Dosage orally. Adults 1 to 2 tablets, 3 to 4 times a day; the elderly daily consumption of not more than 5.
Side effectsDiarrhea , Heartburn , nausea , gastrointestinal discomfort , vomiting , somnolence , skin rush , gastrointestinal hemorrhage
InteractionsBromfenac , (Atropine sulfate (Ophtalmic , Aripiprazole , Alteplase , Amphotericin B , Amikacin , Adefovir , Antithrombin alfa , Anistreplase , Bemiparin , Argatroban , Abciximab , Bacitracin , Anagrelide , Benazepril , Ardeparin , probenecid , Atazanavir , Amiloride , Aspirin , Amoxapine , Apixaban , Blonanserin , Florbetapir F18
characterized by little cause gastrointestinal bleeding.
because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome
Benoral should not be administered concomitantly with probenecid or any other uricosuric agents that decrease tubular reabsorption as any form of salicylate antagonises this effect when given in doses of less than 5 gm per day.