Drug information of iobenguane I 131
Mechanism of effect
Iobenguane I 131 is an I 131 labeled radiopharmaceutical which is similar in structure to the neurotransmitter norepinephrine and subject to the same norepinephrine uptake and accumulation pathways. Iobenguane is taken up by the norepinephrine transporter in adrenergic nerve terminals and accumulates in innervated adrenergic tissues (eg, heart, lungs, adrenal medulla, salivary glands, liver, and spleen, as well as tumors of neural crest origin). Pheochromocytoma and paraganglioma are neural crest origin tumors which express high norepinephrine transporter levels on cell surfaces. Iobenguane I 131 is taken up and accumulates within pheochromocytoma and paraganglioma cells; radiation from radioactive decay of I 131 results in cell death and tumor necrosis.
Distribution: Vd: 2,893 ± 592 mL/kg
Protein binding: 61% to 63% (nonradioactive form); to human plasma proteins
Metabolism: Does not undergo hepatic metabolism
Half-life elimination: Mean terminal blood half-life: 35 ± 14 hours
Time to peak: Generally occurs at the end of infusion
Excretion: Urine (primarily)
Drug indicationspatients with pheochromocytoma
Side effectsAlopecia , Headache , weight decrease , nausea , dry mouth , vomiting , vertigo , Hypertension , hypotension , Phosphate Alkaline increased , elevated INR , tiredness , Colorectal Cancer
InteractionsDexmethylphenidate , Ioxaglate , Levomilnacipran , Iothalamate Meglumine , Meningococcal conjugate vaccine , Bupropion , Tramadol , Labetalol , Methyldopa , Mesalazine , Chloramphenicol , Clozapine , Yohimbine , Droxidopa
Points of recommendation
- • If you have an allergy to iobenguane or any other part of this drug.
- • If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- • If you have any of these health problems: Low white blood cell count, low platelet count, or low red blood cell count.
- • If you are breast-feeding. Do not breast-feed during treatment and for 80 days after your last dose.
- This is not a list of all drugs or health problems that interact with this drug.
- Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.