Drug information of Cefoperazone

• Endometritis
• Febrile Neutropenia
• Intraabdominal Infection
• Joint Infection
• Pelvic Inflammatory Disease
• Peritonitis
• Pneumonia
• Pyelonephritis
• Bacteremia
• Skin or Soft Tissue Infection
• Urinary Tract Infection

Usual Adult Dose for Endometritis

• 1 to 2 g IV or IM every 12 hours to continue until 48 hours after clinical improvement has been observed. Appropriate oral antibiotic therapy may continue until 14 days of therapy has been completed.

Usual Adult Dose for Febrile Neutropenia

• 1 to 2 g IV or IM every 12 hours. Therapy should be continued for 14 days, or until more specific therapy can be instituted for an identified pathogen, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has reached at least 500 cells/mm3.

Usual Adult Dose for Intraabdominal Infection

• 1 to 2 g IV or IM every 12 hours for 7 to 14 days.

Usual Adult Dose for Joint Infection

• 1 to 2 g IV or IM every 12 hours for 3 to 4 weeks. Longer therapy, 6 weeks or more, may be required with prosthetic joint infections. In addition, removal of the infected joint may be required.

Usual Adult Dose for Pelvic Inflammatory Disease

• 1 to 2 g IV or IM every 12 hours to continue until 48 hours after clinical improvement has been observed. Appropriate oral antibiotic therapy should then commence and continue until 14 days of therapy has been completed.
  
  Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

Usual Adult Dose for Peritonitis

• 1 to 2 g IV or IM every 12 hours for 10 to 14 days.

Usual Adult Dose for Pneumonia

• 1 to 2 grams IV or IM every 12 hours for 7 to 21 days depending upon the causative organism.

• 1 to 2 g IV or IM every 12 hours for 14 days.

• 2 g IV or IM every 12 hours for 14 days.

• 1 to 2 g IV or IM every 12 hours for 7 days or for 3 days after inflammation subsides depending on the nature and severity of infection. For more severe infections such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

• 1 g IV or IM every 12 hours for 3 to 7 days.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
• Irritation where cefoperazone is given.
• Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Diarrhea.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

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- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
- If you are allergic to cefoperazone; any part of cefoperazone; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

• This medicine may interact with other drugs or health problems.Tell all of your health care providers that you take cefoperazone. This includes your doctors, nurses, pharmacists, and dentists.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Avoid alcohol and products that have alcohol in them while taking cefoperazone and for at least 72 hours after your last dose. Drinking alcohol or taking products that have alcohol in them, like some cough syrups, may cause flushing, sweating, headaches, and fast heartbeat.
• Very bad and sometimes deadly allergic reactionshave rarely happened. Talk with your doctor.
• This medicine may raise the chance of bleeding. Sometimes, bleeding can be life-threatening. Talk with the doctor.
• Do not use longer than you have been told. A second infection may happen.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take cefoperazone.
• If you have high blood sugar (diabetes), talk with your doctor about which glucose tests are best to use.
• If you are 65 or older, use cefoperazone with care. You could have more side effects.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

Use cefoperazone as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into a muscle or as an infusion into a vein over a period of time.