Drug information of Menotropins

Menotropins

Drug group:

Menotropins are a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are important in the development of follicles (eggs) that are produced by the ovaries in women. Menotropins are used to help your body produce multiple eggs during ovulation, in preparation for in-vitro fertilization.

Mechanism of effect

Stimulates ovarian follicular growth in women who do not have primary ovarian failure

Pharmacodynamic

Used to treat female infertility, Menotropins stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle.

Pharmacokinetics

Menopur Mean follicle-stimulating hormone (FSH) C max is 8.5 milliunit/mL (subcutaneous) and 7.8 milliunit/mL (IM); mean FSH AUC is 762 milliunit•h/mL (subcutaneous) and 656.1 milliunit•h/mL (IM); median T max is 17.9 h (subcutaneous) and 27.5 h (IM). Mean FSH t ½ is 11 to 13 h.

Drug indications

Follicle Stimulation

Dosage

Ovulation induction: Initial dose: 150 international units SC or IM daily for the first 5 days of treatment. Maximum dose: 450 international units daily Duration of therapy: 7 to 12 days

Interactions

Ganirelix

Alerts

1-Before treatment, a thorough gynecologic and endocrinologic evaluation must be performed. Evaluate estradiol levels and ultrasonography results for monitoring growth and development of follicles, timing of hCG administration, and minimizing risk of OHSS and multiple gestation. 2-Monitor patient for signs of excessive ovarian stimulation (eg, abdominal pain or distension, diarrhea, dyspnea, nausea, oliguria, rapid weight gain, severe pelvic pain, vomiting). 3-Monitor patient for signs and symptoms of thromboembolic events (eg, arterial occlusion, pulmonary embolism, pulmonary infarction, stroke, venous thrombophlebitis). 4-Multiple pregnancies have occurred

Points of recommendation

1-To minimize bleeding, do not rub site after injection. 2-OHSS May occur. Warning signs include abdominal distention, nausea, oliguria, pelvic pain, vomiting, weight gain. May progress within 24 h to several days to become a serious medical reaction. 3--If inadequate follicle development or ovulation without subsequent pregnancy, treatment may be repeated.

Pregnancy level

X

Related drugs

Follitropin alfa


Ask a Pharmacist


User's questions
    No comments yet.