Drug information of Aminohippurate Sodium

Aminohippurate Sodium

Drug group: urology

Aminohippurate Sodium is an agent to measure effective renal plasma flow (ERPF). It is the sodium salt of para-aminohippuric acid, commonly abbreviated “PAH”.

Mechanism of effect

Undergoes glomerular filtration; ~90% proximal tubular secretion in a single circulation

Used to measure the functional activity of the renal tubular secretory mechanism or transport maximum (TmPAH)

Pharmacokinetics

Renal Clearance: ~90% in a single circulation at low plasma concentrations

Excretion: Urine

Drug indications

Renal Function Diagnostic

Dosage

Used for estimation and measurement of renal function (effective renal plasma flow and tubular secretion)

Goal is to maintain plasma concentration of 2 mg/dL

Load 6-10 mg/kg, infuse at 10-24 mg/min

Drug contraindications

Hypersensitivity

Hypersensitivity

Side effects

Angioedema , flushing , urticaria

Patients have sensations of warmth or desire to defecate or urinate during or after infusion

Hypersensitivity reactions

  • Angioedema, flushing, vasomotor disturbances
  • Tingling
  • Urticaria
  • Nausea, vomiting & cramps
  • Anaphylaxis

aspirin rectal-aspirin/citric acid/sodium bicarbonate-choline magnesium trisalicylate-ibuprofen IV-ketorolac intranasal-rose hips-salicylates (non-asa)-thiazolesulfone-willow bark

Alerts

-Low cardiac reserve

-Latex sensitive individuals: Vial stopper contains dry natural latex

-Administer IV solutions with caution to patients with low cardiac reserve (rapid increase in plasma volume may precipitate congestive heart failure

Points of recommendation

-Your doctor will check your progress closely while you are receiving aminohippurate sodium.

-The vial stopper of aminohippurate sodium contains dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you receive aminohippurate sodium.

-Do not take other medicines unless they have been discussed with your doctor.

Pregnancy level

C

C

Animal reproduction studies have not been done with PAH. It is also not known whether PAH can cause fetal harm when given to a pregnant woman or can affect reproduction capacity. PAH should be given to a pregnant woman only if clearly needed.

Breast feeding warning

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PAH is administered to a nursing woman.

Drug forms

para-aminohippurate (PAH)

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