Drug information of spinosad
Mechanism of effect
The pharmacodynamics of Natroba Topical Suspension has not been studied.
Natroba (spinosad) Topical Suspension is indicated for the topical treatment of head lice infestation in patients six (6) months of age and older.
Shake bottle well. Apply sufficient Natroba Topical Suspension to cover dry scalp, then apply to dry hair. Depending on hair length, apply up to 120 mL (one bottle) to adequately cover scalp and hair. Leave on for 10 minutes, then thoroughly rinse off Natroba Topical Suspension with warm water. If live lice are seen 7 days after the first treatment, a second treatment should be applied. Avoid contact with eyes.
Itching, burning, flaking, or redness of the scalp
redness of the eye or skin
dryness of the scalp
thinning of the hair
Points of recommendation
For topical use only. Natroba Topical Suspension is not for oral, ophthalmic, or intravaginal use
US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Breast feeding warning
No information is available on the clinical use of spinosad during breastfeeding. Because it is not systemically absorbed after topical application, it should not be present in breastmilk. However, the topical suspension contains benzyl alcohol, which may be systemically absorbed through the skin. High doses of benzyl alcohol are potentially toxic to neonates, but it is unlikely that doses this high reach breastmilk. The manufacturer states that mothers concerned about benzyl alcohol could pump and discard breastmilk for 8 hours, but this is probably unnecessary. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.