Drug information of Halcinonide


Drug group:

Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment
Research suggests that clobetasol propionate demonstrates superior pharmacologic efficacy in the treatment of psoriasis when compared to halcinonide

:Dosage Forms & Strengths
Cream/Ointment: 0.1%

Mechanism of effect

Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation


Not Available


Absorption: Minimal; nature of skin at application; occlusion and inflammation may increase absorption


Excretion: Urine


Topical: Apply sparingly 2-3 times/day; for severe dermatoses may use occlusive dressing

Thin film is effective


Cyclosporine , prednisone


Chronic topical corticosteroid therapy may interfere with growth and development in children

Use med to very high potency for <2 wk to reduce local and systemic side effects

Use low potency for chronic therapy

Kaposi's sarcoma reported with prolonged corticosteroid therapy

Children may exhibit greater susceptibility to corticosteroid-induced HPA axis suppression and Cushing's syndrome due to larger skin surface area to body weight ratio

Points of recommendation

:Adverse Effects
Skin atrophy, Striae, Intracranial hypertension, Contact dermatitis, Perioral dermatitis, Burning, Irritation, Folliculitis, Hypertrichosis, Acneform lesions, Pigmentation changes, HPA suppression with higher potency used >2 wk

Underlying infection, Hypersensitivity and Ophthalmic use

Pregnancy level

Pregnancy Category: C

Breast feeding warning

Excretion of topical corticosteroids in breast milk is unknown; use with caution

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