Drug information of Mometasone


Drug group:

Mometasone is a corticosteroid indicated for the relief of the inflammatory and pruritic  manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older.

Mechanism of effect

The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins.

It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.


Like other topical corticosteroids, Mometasone has anti-inflammatory, antipruritic, and vasoconstrictive properties.


The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Studies in humans indicate that approximately 0.4% of the applied dose of Mometasone enters the circulation after 8 hours of contact on normal skin without occlusion.

 Inflammation and/or other disease processes in the skin may increase percutaneous absorption.

Drug indications

Corticosteroid-responsive Dermatoses



Corticosteroid-responsive dermatoses:

Topical: Apply sparingly, do not use occlusive dressings. Therapy should be discontinued when control is achieved; consider reassessment of diagnosis if no improvement is seen within 2 weeks.

Cream, ointment: Apply a thin film to affected area once daily

Lotion, solution: Apply a few drops to affected area once daily


Corticosteroid-responsive dermatoses:  

Topical: Apply sparingly, do not use occlusive dressings. Therapy should be discontinued when control is achieved; consider reassessment of diagnosis if no improvement is seen within 2 weeks.

Cream, ointment: Children ≥2 years and Adolescents: Refer to adult dosing. Do not use in pediatric patients for longer than 3 weeks.

Lotion, solution: Children ≥12 years and Adolescents: Refer to adult dosing.

Drug contraindications

Hypersensitivity to this drug or components

Hypersensitivity to Mometasone, other corticosteroids, or any component of the formulation; viral (eg, herpes or varicella) lesions of the skin, fungal or bacterial skin infections, parasitic infections, skin manifestations relating to tuberculosis or syphilis, eruptions following vaccinations, acne vulgaris, rosacea, pruritus without inflammation; ophthalmic use; use with occlusive dressings.

Side effects

itching , stinging

Acneiform reaction, burning, tingling, stinging, folliculitis, furunculosis, pruritus, rosacea, skin atrophy (including shininess, telangiectasia, loss of elasticity, loss of normal skin markings, thinness, bruising).

Corticosteroids: Potential pharmacologic interaction with other corticosteroid-containing preparations.
Nitroblue-tetrazolium test for bacterial infection: Concurrent use of corticosteroids reportedly may result in false-negative results.


  • Adrenal suppression: May cause hypercortisolism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children or in patients receiving high doses for prolonged periods. HPA axis suppression may lead to adrenal crisis.
  • Contact dermatitis: Allergic contact dermatitis can occur and is usually diagnosed by failure to heal rather than clinical exacerbation; discontinue use if irritation occurs and treat appropriately.
  • Immunosuppression: Prolonged use may result in fungal or bacterial superinfection; discontinue if dermatological infection persists despite appropriate antimicrobial therapy.
  • Systemic effects: Topical corticosteroids may be absorbed percutaneously. Absorption of topical corticosteroids may cause manifestations of Cushing's syndrome, hyperglycemia, or glycosuria. Absorption is increased by the use of occlusive dressings, application to denuded skin, or application to large surface areas.
  • Elderly : Because of the risk of adverse effects associated with systemic absorption, topical corticosteroids should be used cautiously in the elderly in the smallest possible effective dose for the shortest duration.
  • Pediatric: Not for treatment of diaper dermatitis. Children may absorb proportionally larger amounts after topical application and may be more prone to systemic effects. HPA axis suppression, intracranial hypertension, and Cushing syndrome have been reported in children receiving topical corticosteroids. Prolonged use may affect growth velocity; growth should be routinely monitored in pediatric patients.

Points of recommendation

To make sure this medicine is safe for you, tell your doctor if you have:

  • If you have an allergy to mometasone or any other part of mometasone (topical).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

Do not use to treat diaper rash.

Do not use tight-fitting diapers or plastic pants if treated part is in the diaper area. This may cause more drug to get into the body.

Do not put on cuts, scrapes, or damaged skin.

Use care when putting on a large part of the skin or where there are open wounds. Talk with the doctor.

Do not use mometasone (topical) for longer than you were told by your doctor.

Use with care in children. Talk with the doctor.

This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using mometasone (topical) while you are pregnant.

Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Use as you have been told, even if your signs get better.

Do not take mometasone (topical) by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).

Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.

Clean affected part before use. Make sure to dry well.

Put a thin layer on the affected skin and rub in gently.

Do not use coverings (bandages, dressings, make-up) unless told to do so by the doctor.

Put on a missed dose as soon as you think about it.

If it is close to the time for your next dose, skip the missed dose and go back to your normal time.

Do not put on 2 doses or extra doses.

Pregnancy level


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