Drug information of Moxifloxacin

Moxifloxacin

Drug group:

Moxifloxacin is an antibiotic in a group of drugs called fluoroquinolones (flor-o-KWIN-o-lones). Moxifloxacin fights bacteria in the body. Moxifloxacin is used to treat different types of bacterial infections of the skin, sinuses, lungs, or stomach.

Mechanism of effect

The bactericidal action of Moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Pharmacodynamic

Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Absolute oral bioavailability is approximately 90%. Food has little effect on absorption. 50% bound to serum proteins, independent of drug concentration. Approximately 45% of an oral or intravenous dose of moxifloxacin is excreted as unchanged drug (~20% in urine and ~25% in feces). Half life: 11.5-15.6 hours (single dose, oral).

Dosage

Usual Adult Dose for Sinusitis Acute bacterial sinusitis: 400 mg orally or IV every 24 hours for 10 days Usual Adult Dose for Skin or Soft Tissue Infection 400 mg orally or IV every 24 hours Duration: 7 to 21 days for complicated infections; 7 days for uncomplicated infections

Alerts

1-TENDON EFFECTS and MYASTHENIA GRAVISFluoroquinolones, including moxifloxacin hydrochloride, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. 2-Fluoroquinolones, including moxifloxacin hydrochloride, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid moxifloxacin hydrochloride in patients with known history of myasthenia gravis.

Points of recommendation

1- Remind patient to complete entire course of therapy, even if symptoms of infection have disappeared. 2- Administer Moxifloxacin 3 h before or 2 h after sucralfate, antacids containing magnesium or aluminum, didanosine chewable buffered tablets or pediatric powder, or other products containing iron or zinc.

Pregnancy level

C


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