Drug information of Moclobemide

Moclobemide

Drug group:

A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.

Mechanism of effect

The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms.

Pharmacodynamic

negligible anticholinergic and antihistaminic actions

Pharmacokinetics

The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms.

Drug indications

depression , Bipolar Disorders

Dosage

Usual Adult Dose
Depression, mental (treatment)

Oral, 150 mg two times a day. The dose may be increased as needed and tolerated to a maximum of 600 mg a day. The initial daily dose of 300 mg should not be increased until after the first week of therapy in order to minimize side effects.

Usual Pediatric Dose
Safety and efficacy have not been established.

Drug contraindications

dizziness , hypersensitivity to this drug

Alerts

Tyramine- or other high pressoramine–containing foods and beverages, such as aged cheese; fava or broad bean pods; yeast/protein extracts; smoked or pickled meats, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; sauerkraut; any overripe fruit; beer; reduced-alcohol and alcohol-free beer and wine; red and white wines; sherry; and liqueurs    (concurrent consumption of tyramine-rich food with irreversible monoamine inhibitors may cause sudden and severe hypertensive reactions;,

dietary restrictions may not be necessary; consumption of up to 100 mg of tyramine with 600 mg of moclobemide per day is not expected to cause problems; potential hypertensive reactions may be minimized if moclobemide is taken after meals

Points of recommendation

» Lag time between initiation of moclobemide and therapeutic response

» Taking exactly as directed by physician

» Importance of not taking more medication than the amount prescribed

» Proper dosing
Taking as soon as possible; not taking if almost time for next scheduled dose; not doubling doses

Checking with physician before discontinuing medication; gradual reduction may be needed to prevent withdrawal effects

» Dizziness may occur; caution when getting up suddenly from a lying or sitting position

» Drowsiness or blurred vision may occur; caution when driving or doing things requiring alertness or clear vision

» Avoiding alcoholic beverages, over-the-counter cold, cough, hay fever, or weight-reduction medicines, and other medications, unless prescribed

» Checking with physician if symptoms of hypertensive crisis develop(Bradycardia,neck stiffness,    
occipital headache, palpitations, tachycardia)

Pregnancy level

Not assigned


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