Drug information of Miconazole

Mechanism of effect

Inhibits biosynthesis of ergosterol, damaging the fungal cell wall membrane, which increases permeability causing leaking of nutrients

Pharmacodynamic

Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral),

Pharmacokinetics

Absorption:Minimal Duration of Action:Buccal adhesion: 15 hours

Drug indications

fungal infections

Dosage

Dosing: Adult Oropharyngeal candidiasis: Buccal tablet: 50 mg (1 tablet) applied to the upper gum region once daily for 14 days

Drug contraindications

hypersensitivity to drug or its components.

Side effects

nausea , Headache , abdominal pain , vomiting , fatigue , Diarrhea , pruritus , neutropenia , anemia , Cough , Upper respiratory tract infection , Pain

Interactions

Oxybutynin , Tadalafil , Tamsulosin , Trazodone , Vardenafil , Venlafaxine , chlorpropamide , Eliglustat , Gefitinib , Cannabidiol , ambrisentan

Alerts

1- Although systemic absorption is typically minimal, use with caution in patients with hepatic impairment. 2-Monitor patients with a history of azole hypersensitivity.

Points of recommendation

Miconazole should be discontinued at once at the first sign of hypersensitivity.

Pregnancy level

C

Related drugs

Fluconazole , Ketoconazole , Clotrimazole