Drug information of Miconazole
Mechanism of effect
Inhibits biosynthesis of ergosterol, damaging the fungal cell wall membrane, which increases permeability causing leaking of nutrients
Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral),
Absorption:Minimal Duration of Action:Buccal adhesion: 15 hours
Drug indicationsfungal infections
Dosing: Adult Oropharyngeal candidiasis: Buccal tablet: 50 mg (1 tablet) applied to the upper gum region once daily for 14 days
Drug contraindicationshypersensitivity to drug or its components.
Side effectsnausea , Headache , abdominal pain , vomiting , fatigue , Diarrhea , pruritus , neutropenia , anemia , Cough , Upper respiratory tract infection , Pain
InteractionsOxybutynin , Tadalafil , Tamsulosin , Trazodone , Vardenafil , Venlafaxine , chlorpropamide
1- Although systemic absorption is typically minimal, use with caution in patients with hepatic impairment. 2-Monitor patients with a history of azole hypersensitivity.
Points of recommendation
Miconazole should be discontinued at once at the first sign of hypersensitivity.