Drug information of Naphazoline

Naphazoline


Naphazoline is a rapid acting sympathomimetic vasoconstrictor of occularartierioles and nasal vessels. It acts to decrease congestion of the vessels and is found in many over-the-counter drops.

Mechanism of effect

Naphazoline constricts the vascular system of the conjunctiva. It is presumed that this effect is due to direct stimulation action of the drug upon the alpha-adrenergic receptors in the arterioles of the conjunctiva, resulting in decreased conjunctival congestion.

Pharmacodynamic

Naphazoline Hydrochloride is the hydrochloride salt form of naphazoline, an imidazolederivative and a direct-acting sympathomimetic amine with vasoconstrictive properties. 

Pharmacokinetics

Following topical application of naphazoline hydrochloride solutions to the conjunctiva, local vasoconstriction usually occurs within 10 minutes and may persist for 2-6 hours. Occasionally, enough naphazoline may be absorbed to produce systemic effects. Information on the distribution and elimination of the drug in humans is not available

Drug indications

nasal stuffiness , itchy eyes

Dosage

Instill one or two drops in the conjunctival sac(s) every three to four hours as needed.

Alerts

Patients under therapy with MAO inhibitors may experience a severe hypertensive crisis if given a sympathomimetic drug. Use in children, especially infants, may result in CNS depression leading to coma and marked reduction in body temperature.

Points of recommendation

It is For topical use only. Use with caution in presence of hypertension, cardiovascular abnormalities, hyperglycemia (diabetes), hyperthyroidism, infection or injury.

 Patients should be advised to discontinue the drug and consult the physician if relief is not obtained within 48 hours of therapy, if irritation, blurring or redness persists or increases, or if symptoms of systemic absorption occur, i.e., dizziness, headache, nausea, decrease in body temperature, or drowsiness.

Pregnancy level

C


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