Drug information of Nitrofurazone

Mechanism of effect

The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase

Pharmacodynamic

The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase

Pharmacokinetics

Absorption: Well absorbed.

Metabolism: nitrofurazone, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules

Half life: 5 hours

Dosage

Adult and adolescent
Burns orSkin infections
Topical, directly to lesion or place on gauze, once daily or every few days, depending on the usual dressing technique.
pediatric
Safety and efficacy have not been established.

Interactions

probenecid

Alerts

The use of nitrofurazone occasionally allows overgrowth of nonsusceptible organisms including fungi andPseudomonas . If this occurs, or if irritation, sensitization, or superinfection develops, treatment should be discontinued

Points of recommendation

Applying sufficient medication to affected area  or placing medication on gauze to cover affected area
Missed dose: Applying as soon as possible; not applying if almost time for the next dose

Pregnancy level

C

Related drugs

Erythromycin , Tetracycline , Gentamicin , Sulfacetamide , Silver sulfadiazine , Mupirocin , Bacitracin , Neomycin