Drug information of Nystatin

Nystatin

Drug group:

Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei.

Mechanism of effect

Nystatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

Pharmacodynamic

Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. Nystatin acts by binding to sterols in the cell membrane

Pharmacokinetics

Gastrointestinal absorption of nystatin is insignificant. Most orally administered nystatin is passed unchanged in the stool. In patients with renal insufficiency receiving oral therapy with conventional dosage forms, significant plasma concentrations of nystatin may occasionally occur. Onset of Action Hyperglycemic Oral: Within 1 hour

Dosage

Usual Adult Dose for Oral Thrush
Recommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a day Duration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradication .
Comment:
-For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.
Use: Treatment of oral candidiasis in the oral cavity

Usual Adult Dose for Intestinal Candidiasis
Recommended dose: 500,000 to 1,000,000 units of the tablet formulation orally 3 times a day Duration of therapy: At least 48 hours after clinical cure
Use: Treatment of non-esophageal mucus membrane gastrointestinal candidiasis

Usual Pediatric Dose for Oral Thrush
1 month to 12 months:
-Recommended dose: 200,000 units of the oral suspension orally 4 times a day
1 year to 18 years:
-Recommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a day
-Duration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradication
Comments:
-Limited data in premature and low birth weight infants indicated efficacy with 100,000 units orally 4 times a day.
-Infants should avoid feeding for 5 to 10 minutes after administration.
-For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.
Use: Treatment of oral candidiasis in the oral cavity

Alerts

This medication is not to be used for the treatment of systemic mycoses. Discontinue treatment if sensitization or irritation is reported during use.

Points of recommendation

Do NOT use nystatin if :
you are allergic to any ingredient in nystatin
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with nystatin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
Some MEDICINES MAY INTERACT with nystatin . However, no specific interactions with nystatin are known at this time.

Pregnancy level

C


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