Drug information of Nifedipine

Nifedipine

Drug group:

Nifedipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Nifedipine is used to treat hypertension (high blood pressure) and angina (chest pain)

Mechanism of effect

Nifedipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle

Pharmacodynamic

Nifedipine, the prototype of the dihydropyridine class of calcium channel blockers (CCBs)

Pharmacokinetics

Nifedipine is rapidly and fully absorbed after oral administration. Protein binding: 92-98%. Hepatic metabolism via cytochrome P450 system. Nifedipine is extensively metabolized to highly water-soluble, inactive metabolites accounting for 60 to 80% of the dose excreted in the urine. The remainder is excreted in the feces in metabolized form, most likely as a result of biliary excretion. Half life: 2 hours.

Dosage

Usual Adult Dose for Hypertension Initial dose: Extended release tablets: 30 to 60 mg orally once a day Dosage can be increased gradually every 7 to 14 days. Maximum dose: Adalat (R) CC: 90 mg/day Procardia XL (R): 120 mg/day Usual Pediatric Dose for Hypertension Extended release tablets: Children: 0.25 to 0.5 mg/kg/day in 1 to 2 divided doses; dose should be titrated to effect Maximum dose: 3 mg/kg/day up to 120 mg/day (or 180 mg/day in some centers) Adolescents: Initial dose: 30 mg orally once a day

Alerts

1-Because nifedipine decreases peripheral vascular resistance, careful monitoring of blood pressure during the initial administration and titration of nifedipine is suggested. 2-Mild to moderate peripheral edema, typically associated with arterial vasodilation and not due to left ventricular dysfunction, occurs in about one in ten patients treated with nifedipine. 3-Rare, usually transient, but occasionally significant elevations of enzymes such as alkaline phosphatase, CPK, LDH, SGOT, and SGPT have been noted.

Points of recommendation

1-You may need to take an extended-release tablet on an empty stomach. 2-Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office. 3-If you are being treated for high blood pressure, keep using this medication even if you feel well 4-Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. 5-Grapefruit and grapefruit juice may interact with nifedipine and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Pregnancy level

C


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