Mechanism of effect
After topical application to the eye, blocks responses of the sphincter muscle of the iris and the accommodative ciliary muscle of the ciliary body to cholinergic stimulation.
Pharmacodynamic
This anticholinergic preparation blocks the responses of the sphincter muscle of the iris and the accommodative muscle of the ciliary body to cholinergic stimulation, producing pupillary dilation (mydriasis) and paralysis of accommodation (cycloplegia).
Pharmacokinetics
Following topical application to the eye, mydriatic agents are absorbed systemically, principally through the conjunctiva and nasal mucosa.
Following topical application to the eye, maximum mydriasis occurs in about 10–30 minutes, and maximum cycloplegia occurs in about 30–90 minutes. Mydriasis may last 6 hours to 4 days, and cycloplegia persists about 10–48 hours.
Distribution in ocular tissues not fully characterized. Not known whether homatropine is distributed into milk after topical application to the eye.
Dosage
· Pediatric Patients
Use only the 2% solution in pediatric patients.
Ophthalmologic Examination
1 drop of a 2% solution in the eye(s) immediately before the procedure; may repeat at 10-minute intervals as necessary.
Uveitis
1 drop of a 2% solution in the eye(s) 2 or 3 times daily.
· Adults
Ophthalmologic Examination
1 or 2 drops of a 2 or 5% solution in the eye(s) immediately before the procedure; may repeat in 5–10 minutes if necessary.
Uveitis
1 or 2 drops of a 2 or 5% solution in the eye(s) 2 or 3 times daily or, if necessary, up to every 3–4 hours.
Drug contraindications
hypersensitivity to this drugSide effects
edema , nausea , Headache , vomiting , Blurred vision , Photosensitivity , local irritation , allergic reactionsInteractions
Acetylcholine , Topiramate , Nitroglycerin , pilocarpine oral , Pramlintide , Huperzine AAlerts
Concomitant Conditions: Consider risks and benefits in patients with keratoconus (homatropine may produce fixed dilated pupil), Down’s syndrome, and children with brain damage.
Sensitivity Reactions: Discontinue if signs or symptoms of sensitivity occur during treatment.
Systemic Effects: Excessive use, especially in children, geriatric patients, or other susceptible individuals, may produce adverse systemic antimuscarinic effects, including delirium, agitation, and coma. Parenteral physostigmine is the recommended antidote for systemic anticholinergic symptoms.
Points of recommendation
You should not use this medicine if you are allergic to homatropine, or if you have:
- glaucoma, or
- if your eye doctor has found changes in your eyes that could be signs of glaucoma.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether homatropine ophthalmic passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not use this medicine while wearing contact lenses. Homatropine ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.
To treat uveitis, you may need to use homatropine ophthalmic every 3 to 4 hours.
Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.
Do not use the eye drops if the liquid has changed colors or has particles in it.
Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.
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