Drug information of Human papillomma virus vaccine
Human papillomma virus vaccine
Gardasil is used to prevent genital warts and cervical/vaginal/anal cancers caused by human papillomavirus (HPV) types 6, 11, 16, and 18 in girls and young women ages 9 through 26. Gardasil is also used to prevent genital warts caused by HPV types 6 and 11 in boys and young men ages 9 through 26. Human papillomavirus (HPV) can cause genital warts, cancer of the cervix, and various cancers of the vulva or vagina.
Mechanism of effect
Human beings develop a humoral immune response to the vaccine, although the exact mechanism of protection is unknown
HPV only infects human beings. Animal studies with analogous animal papillomaviruses suggest that the efficacy of L1 VLP vaccines may involve the development of humoral immune responses
Drug indicationsprevention of the following diseases caused by Human Papillomavirus (HPV) types included in the vaccine
GARDASIL should be administered intramuscularly as a 0.5-mL dose at the following schedule: 0, 2 months, 6 months.
hypersensitivity to drug or its components.
nausea , Headache , abdominal pain , dizziness , vomiting , Diarrhea , fever , myalgia , Upper respiratory tract infection , Nasopharyngitis
InteractionsInterferon beta-1b , Thymoglubin , Fingolimod , Mycophenolate mofetil , Natalizumab , Contraceptive , Contraceptive DE , Contraceptive HD , Contraceptive LD , Prednisolone , Golimumab , Canakinumab , Basiliximab , Alefacept , Rilonacept , secukinumab
1-Because vaccinees may develop syncope, sometimes resulting in falling with injury, observation for 15 minutes after administration is recommended 2-Appropriate medical treatment and supervision must be readily available in case of anaphylactic reactions following the administration of Gardasil.
Points of recommendation
1-Vaccination does not eliminate the necessity for women to continue to undergo recommended cervical cancer screening. Women who receive Gardasil should continue to undergo cervical cancer screening per standard of care 2-Recipients of Gardasil should not discontinue anal cancer screening if it has been recommended by a health care provider. 3-Gardasil has not been demonstrated to provide protection against disease from vaccine and non-vaccine HPV types to which a person has previously been exposed through sexual activity. 4-Gardasil is not recommended for use in pregnant women.