Drug information of Clarithromycin

Clarithromycin

Drug group:

Clarithromycin is a macrolide antibiotic. It fights bacteria in your body. Clarithromycin is used to treat many different types of bacterial infections affecting the skin and respiratory system. It is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori.

Mechanism of effect

action Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.

Pharmacodynamic

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia.

Pharmacokinetics

Clarithromycin is rapidly absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability of 250 mg Clarithromycin tablets was approximately 50%. After a 250 mg tablet every 12 hours, approximately 20% of the dose is excreted in the urine as clarithromycin, while after a 500 mg tablet every 12 hours, the urinary excretion of clarithromycin is somewhat greater, approximately 30%. Half life:3-4 hours

Dosage

Usual Adult Dose for Tonsillitis/Pharyngitis Immediate-release: 250 mg orally every 12 hours for 10 days Usual Adult Dose for Sinusitis Immediate-release: 500 mg orally every 12 hours for 14 days

Interactions

Alprazolam , Aprepitant , Ergotamine-C , Erlotinib , Everolimus , Oxybutynin , Ipratropium bromide , Itraconazole , Irinotecan , Ifosfamide , Imatinib , Budesonide , Bosentan , Protamine sulfat , Pimozide , Tadalafil , Tamsulosin , Tacrolimus , Tetrabenazine , Trazodone , Topotecan , Daunorubicin , Deflazacort , Dexamethasone , Disopyramide , Repaglinide , Zonisamide , Salbutamol , Sunitinib , Sertraline , Sotalol , Citalopram , Cisapride , Sildenafil , Simvastatin , Cyclosporine , Fluoxetine , Glibenclamide , Glimepiride , Lansoprazole , Lapatinib , Loratadin , Lovastatin , Methylprednisolone , Medroxyprogesterone , Mexiletine , Midazolam , Neostigmine , Nilotinib , Nimodipine , Vardenafil , Venlafaxine , Cabergoline , Carbamazepine , Colchicine , Clozapine , Rivaroxaban , Disulfiram , Bisoprolol , fentanyl , Rifabutin , Ranolazine , Toremifene , pravastatin , Ziprasidone , propoxyphene , Axitinib , Almotriptan , ritonavir , saquinavir , nelfinavir , nevirapine , eletriptan , Ivabradine , Prednisolone , Dolasetron , vandetanib , Droperidol , sparfloxacin , Indinavir , Procainamide , Mefloquine , Ribociclib , Indapamide , Dofetilide , Inotuzumab‎ , Ivacaftor , brigatinib , Abiraterone , Budesonide , Dalteparin , nasal Mometasone , Dutasteride , Arsenic trioxide , Copanlisib , Tipranavir , Tinzaparin , Simeprevir , lumacaftor and Ivacaftor , Etravirine , Dabrafenib , Estropipate , Acalabrutinib , Cabazitaxel , Maraviroc , Halofantrine , Grepafloxacin , Darifenacin , Terfenadine , Fesoterodine , Alfuzosin , Ergoloid Mesylate , Erdafitinib , Pazopanib , Palbociclib , Ixazomib , Pimavanserin , Tasimelteon , Betrixaban , trabectedine , Duvelisib , lenvatinib , pexidartinib , elagolix , Flibanserin , Avanafil , Estazolam , Edoxaban , Entrectinib , cholera vaccine live , Lopinavir and Ritonavir , Levomilnacipran , ELBASVIR/GRAZOPREVIR , Lorlatinib , Larotrectinib , gilteritinib , glasdegib , Abemaciclib , Eliglustat , Suvorexant , Ruxolitinib , Calcium pantothenate , tolvaptan , Bepridil , bazedoxifene/conjugated estrogens , bedaquiline , Gefitinib , Dasatinib , Gemtuzumab , Remdesivir , neratinib , Cannabidiol , talazoparib , vemurafenib , Typhoid vaccine (live), oral , vorapaxar , Macitentan , voxelotor , Avapritinib , Fidaxomicin , Capmatinib , Bacampicillin , Halaven

Alerts

1-Clarithromycin SHOULD NOT BE USED IN PREGNANT WOMEN EXCEPT IN CLINICAL CIRCUMSTANCES WHERE NO ALTERNATIVE THERAPY IS APPROPRIATE 2-Hepatic dysfunction, including increased liver enzymes, and hepatocellular and/or cholestatic hepatitis, with or without jaundice, has been reported with Clarithromycin. 3-Clarithromycin has been associated with prolongation of the QT interval and infrequent cases of arrhythmia.

Points of recommendation

1-Discontinue Clarithromycin immediately if signs and symptoms of hepatitis occur. 2-Clarithromycin tablets can be taken with or without food and can be taken with milk.

Pregnancy level

C


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