Drug information of Clotrimazole
Mechanism of effect
Clotrimazole Cream is an antifungal agent. It kills sensitive fungi by binding to the fungal cell membrane and weakening it. This allows the cell contents to leak out and results in the death of the fungus.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Negligible through intact skin (3-10% absorbed with intravaginal dose)
Time to peak: ~24 hr (vaginal cream)
Drug indicationsCutaneous Candidiasis , treatment of tineapedis , tineacruris , tineacorporus , Vaginal Candidiasis , Superficial Dermatologic Infection
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
for Vaginal Candidiasis :
• Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
• Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
Drug contraindicationsHypersensitivity to this drug or components
Side effectsnausea , fever , itching , stinging , swelling , stomach upset , stomach pain , redness , foul-smelling discharge if using the vaginal produ
• Avoid contact with eyes
• Some dosage forms contain benzyl alcohol; large amounts of benzyl alcohol have been associated with gasping syndrome (potentially fatal) in neonates
• Not for use by patients who have never had a vaginal infection diagnosed by a doctor
• Not for use with tampons, douches, spermicides, or other vaginal products
• Condoms and diagrams may damage and fail to prevent pregnancy or sexually transmitted disease
• Not for use when having vaginal intercourse
• May cause mild increase in vaginal burning, itching or irritation
• Patient should ask doctor if symptoms do not get better in 3 days, symptoms last more than 7 days, or experience rash, abdominal pain, fever, chills, nausea, vomiting, or a foul smelling vagina discharge
Points of recommendation
• Clotrimazole Cream is for topical use on the skin only.
• Clean the affected area with soap and water and dry thoroughly.
• Apply a thin layer of medicine to the affected area. Rub it in gently. Do not cover unless directed to by your doctor.
• Wash your hands immediately after using Clotrimazole Cream, unless your hands are part of the treated area.
• To clear up your infection completely, use Clotrimazole Cream for the full course of treatment. Keep using it even if you feel better in a few days.