Drug information of Policosanol


Drug group:

Policosanol is obtained from sugar cane and it is used as a dietary supplement. It reduces cholesterol synthesis.

Mechanism of effect

Policosanol impact on cholesterol is mediated through a reduction in the synthesis and degradation of the rate-limiting step of cholesterol biosynthesis, the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) redutase.

 In hepatoma cells and mouse liver, policosanol promoted the phosphorylation of adenosine monophosphate kinase, the principle enzyme for catalyzing the phosphorylation of HMG CoA reductase, thereby reducing its activity. It affects low-density lipoprotein (LDL) metabolism through increasing LDL binding, uptake and degradation.


Decrease cholesterol production in the liver. It also decreases the stickiness of platelets in the blood.


Tab 10 and 20 mg



It is typically initiated at 5 mg/day and titrated up to 20 mg/day


Pregnancy and breast-feeding

Bleeding disorders


Points of recommendation

Stop using policosanol at least 2 weeks before a scheduled surgery

Pregnancy level

Not assigned

Related drugs

Mipomersen , tiadenol

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