Drug information of Senagol
Constipation , and for bowel evacuation. Each 5 ml of senagol children’s syrup contain 8.8 mg sennosides A,B . The active ingredients of senna leaves are Anthraquinones, primarily sennosides A and B ( rhein dianthrones ) with sennosides C and D ( rhein aloe - emodin heterodianthrone ) . Polysaccharides including mucilage and Flavenoids including isorhamnetin,and kaempferol.
Mechanism of effect
The cathartic action of Anthraquinone - containing drugs is well recognized. These drugs have been used as laxatives for many years. It is thought that anthraquinone glycosides are absorbed from the gastro-intestinal tract, the aglycones liberated during metabolism and excreted into the colon resulting in bowel movement stimulation and an increase in peristalsis (1,2). Sennosides A, B , and their natural metabolites sennidins A and B, have been reported to act specifically on the large intestine with the acceleration of colonic transport, the major component of their laxative effect . Sennosides A and B have also been reported to induce fluid secretion exclusively in the colon, following oral administration of the glycosides (3).
Children 6 to 12 years of age 1-1.5teaspoonful once a day or maximally twice a day . Children 2 to under 6 years of age 0.5-1 teaspoonful once a day or maximally twice a day.
Drug contraindicationsbowel obstruction
It is recommended that senna should not be given to patients with intestinal obstruction or with undiagnosed abdominal symptoms . Care should also be taken by patients with inflammatory bowel disease and prolonged use should be avoided.Excessive use of senna may potentiate the action of cardiac glycosides due to excessive potassium loss. Anthraquinones cause discoloration of the urine which may interfere with diagnostic tests.
Points of recommendation
Many physicians recommend senagol laxative to relieve constipation effectively and conviently by gentle stimulation of the large bowel . In children , constipation is more often caused by an inadequate and unbalanced diet , insufficient intake of fluid ,a reaction to passing painful stools or stressful changes in their environment .