Drug information of Huperzine A
Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.
Mechanism of effect
Huperzine A has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease.
Clinical trials in China have shown that huperzine A is comparably effective to the drugs currently on the market, and may even be somewhat safer in terms of side effects.
Absorption: readily from GI tract
Distribution: wide, including brain
Peak Plasma Time: 80 min
Metabolism: some first pass metabolism in liver
Alzheimer Disease & Multi-infarct Dementia
50-200 mcg PO BID
Senile or presenile dementia
30 mcg PO BID
Prevention of muscle weakness in myasthenia gravis
400 mcg IM qDay
Drug contraindicationsAsthma , Inflammatory Bowel Disease , cardiac arrhythmias , Seizure Disorders , IBS
Interactionspilocarpine oral , Atracurium , Amitriptyline , Oxybutynin , Ipratropium bromide , Imipramine , Bethanechol , Pilocarpine , Henbane , IncobotulinumtoxinA , glycopyrrolate , Trospium , Cevimeline , Fesoterodine , Rapacuronium , Dosulepin , Rocuronium , Orphenadrine , Echothiophate , Meclizine , Darifenacin , Flavoxate , Pancuronium , protriptyline , Cyclizine , Hyoscyamine , Scopolamine , Tacrine , Donepzil , Atropine , Carbachol , Physostigmine , Amoxapine , Aclidinium , Nortriptyline , Homathropine , Clomipramine , Solifenacin , Cyclobenzaprine , Vecuronium , Diphenhydramin , Succinylcholine , Cis atracurium , Galantamine , Maprotiline , Neostigmine , Trimipramine , Tolterodine , Tiotropium bromid , Desipramine , Doxepin , Dicyclomine , Belladonna , Pralidoxime , Propantheline , Pyridostigmine , Pilocarpine , Trazodone
Points of recommendation