Drug information of Nervoxin
Hypericum perforatum (St. John’s wort) Standardised Ext : 400 mg ( equivalent to 0.5 mg hypericin ) Other constituents are : pseudohypericin , hyperforin , quercitrin , rutin , biflavonoids, chlorogenic acid , condensed tannins , etc. Therapeutic indications: Mild to moderate depression ( and pediatric depression )- Premenstrual syndrome- Menopausal symptoms- Fatigue or loss of energy - Pediatric nocturnal incontinence- Anxiety- Improvement of “ sleep quality “- Improvement of cognitive ability- Seasonal effective disorder.
Mechanism of effect
The antidepressant mechanism of hypericum extract’s action may be due to effects on many neurotransmitters including serotonin , norepinephrine , dopamine , L- glutamate and GABA .The anxiolytic effect of the drug maybe due to benzodiazepine receptor activation . Hypericum ext. reduces anxiety symptoms ( tension , worry , irritability , muscle tightness , bruxism and insomnia).
Antidepressant , Anxiolytic
Adults : 1 to 2 tablets daily , with meal children ( 6-12 years old ) : under medical supervision , half the adult dose . In general , a range of 0.2 to 1 mg/day of hypericin is recommended .
Side effectsnausea , Headache , constipation , allergic reaction , Diarrhea , Photosensitivity , Mild gastrointestinal complaints
Interactionsferric carboxymaltose , Acetaminophen+caffeine , Acetaminophen+caffein+acetylsalic , Acetaminophan+caffeine+ibuprofen , Oxazepam , Theophyline G , Clonazepam , Contraceptive , Contraceptive DE , Contraceptive HD , Contraceptive LD , Diazepam , Cyclosporine , Flurazepam , Lorazepam , Nitrazepam , Warfarin
1- Avoid use of The drug after organ transplants , during pregnancy , with other antidepressant , and with protease -1 inhibitors . 2- Caution is advised if patient take the medications metabolized by cytochrome p450 , tyramine- containing foods , and have a previous history of photosensitization .
Points of recommendation
1- Hypericum ext. has a particularly high level of clinical safety and good tolerability . only few adverse effects noted such as : mild gastrointestinal disturbances ( nausea, diarrhoea or constipation ) , head ache or allergic reactions , and in rare cases restlessness 2- Storage: In a cool and dry place .