Drug information of Glucosamine

Glucosamine


Glucosamine is a naturally occurring substance found in bones, bone marrow, shellfish and fungus.

It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.

Glucosamine has been used in alternative medicine as an aid to relieving joint pain, swelling, and stiffness caused by arthritis

Mechanism of effect

Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis.

Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use.

Pharmacodynamic

Osteoarthritis is characterized by the progressive degeneration of cartilage glycosaminoglycans. The formation of glucosamine is the rate limiting step in glycosaminoglycans synthesis thus the addition is glucosamine, would in theory provide a building block towards the synthesis of glycosaminoglycans and thus slow down the progression of osteoarthritis.

Dosage

Adult : Osteoarthritis, Temporomandibular Joint Arthritis

500 mg PO TID OR

1500 mg PO qDay

Drug contraindications

hypersensitivity to this drug

Alerts

Cautions:

  • Diabetes mellitus
  • Hyperlipidemia
  • Hypertension
  • cancer
  • liver disease
  • asthmaor other breathing disorder
  • hypersensitivity to seafood (derived from shellfish)

Points of recommendation

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use glucosamine, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Do not use different formulations of glucosamine at the same time without medical advice. Using different formulations together increases the risk of an overdose of glucosamine.

This medicine can cause unusual results with a blood glucose (sugar) test. Do not use this product without a doctor's advice if you are diabetic.

If you need surgery, tell the surgeon ahead of time that you are using glucosamine. You may need to stop using the medicine for a short time.

It may take up to 8 weeks before your symptoms improve. For best results, keep using glucosamine as directed.

Call your doctor if your symptoms do not improve, or if they get worse while using glucosamine.

Store at room temperature away from moisture and heat.

Pregnancy level

HAVE NOT BEEN ESTABLISHED

Related drugs

Piascledine


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